Gene Report

Basic Information

Approved Symbol	SLC1A2
Approved Name	solute carrier family 1 (glial high affinity glutamate transporter), member 2
Symbol Alias	GLT-1, EAAT2
Location	11p13-p12
Position	chr11:35272752-35441610 (-)
External Links	Entrez Gene: 6506 Ensembl: ENSG00000110436 UCSC: uc001mwd.3 HGNC ID: 10940
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin; Protein mapped

Positive relationships between SLC1A2 and MDD (count: 3)

Name in Literature	Reference	Research Type	Relation Description
SLC1A2	Bernard, 2010	patients and normal controls	The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
SLC1A2	Choudary, 2005	patients and normal controls	Microarray analysis of specific areas of cerebral cortex fro...... Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. More...
SLC1A2	Klempan, 2009	patients and normal controls	Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between SLC1A2 and other components at different levels (count: 0)

Positive relationship network of SLC1A2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC1A2 and MDD (count: 0)

Negative relationships between SLC1A2 and other components at different levels (count: 0)

SLC1A2 related SNPs in MK4MDD (count: 0)

SLC1A2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Excitatory amino acid transporter 2	P43004	1(1/0)	Literature-origin

SLC1A2 related GO terms (count: 22)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[7521911]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051938	L-glutamate import	biological process	IDA[7521911]
GO:0035264	multicellular organism growth	biological process	IEA
GO:0009611	response to wounding	biological process	IEA
GO:0017153	sodium:dicarboxylate symporter activity	molecular function	IEA
GO:0030673	axolemma	cellular component	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0007632	visual behavior	biological process	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0010259	multicellular organismal aging	biological process	IEA
GO:0055085	transmembrane transport	biological process	TAS
GO:0021537	telencephalon development	biological process	IEA
GO:0016020	membrane	cellular component	TAS[7521911]
GO:0046326	positive regulation of glucose import	biological process	IEA
GO:0043200	response to amino acid stimulus	biological process	IEA
GO:0031668	cellular response to extracellular stimulus	biological process	IEA
GO:0006811	ion transport	biological process	TAS
GO:0070779	D-aspartate import	biological process	IDA[7521911]
GO:0005313	L-glutamate transmembrane transporter activity	molecular function	TAS[7521911]
GO:0030534	adult behavior	biological process	IEA
GO:0015501	glutamate:sodium symporter activity	molecular function	IEA
GO:0042493	response to drug	biological process	IEA

SLC1A2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05014	amyotrophic lateral_sclerosis_als	Amyotrophic lateral sclerosis (ALS)	Amyotrophic lateral sclerosis (ALS) is a progressive, lethal...... Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death. More...

SLC1A2 related BioCarta pathways (count: 0)

SLC1A2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...

SLC1A2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SLC1A2	SLC1A2	Yes	in vivo	15483603
SLC1A2	JUB	No	in vitro;in vivo;yeast 2-hybrid	11860269

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways