MK4MDD

Gene Report

Basic Information
Approved Symbol SLC1A2
Approved Name solute carrier family 1 (glial high affinity glutamate transporter), member 2
Symbol Alias GLT-1, EAAT2
Location 11p13-p12
Position chr11:35441483-35441610 (-)
External Links Entrez Gene: 6506
Ensembl: ENSG00000110436
UCSC: uc001mwd.3
HGNC ID: 10940
No. of Studies (Positive/Negative) 6(3/3) Help
Type Literature-origin; Protein mapped

Positive relationships between SLC1A2 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
SLC1A2 Bernard, 2010 patients and normal controls The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
SLC1A2 Choudary, 2005 patients and normal controls Microarray analysis of specific areas of cerebral cortex fro...... Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. More...
SLC1A2 Klempan, 2009 patients and normal controls Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between SLC1A2 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of SLC1A2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between SLC1A2 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
SLC1A2 Oh DH, 2014 patients and normal controls P-value=0.057 We found two datasets where the mRNA levels of GAD1 and SLC1...... We found two datasets where the mRNA levels of GAD1 and SLC1A2 in subregions of the dlPFC were significantly and marginally lower in subjects with MDD (n = 15) than in controls (n = 15) (p = 0.045 and 0.057, respectively) More...
SLC1A2 Chandley MJ, 2013 patients and normal controls

Negative relationships between SLC1A2 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


SLC1A2 related SNPs in MK4MDD (count: 0)
SLC1A2 related proteins in MK4MDD (count: 1)
SLC1A2 related GO terms (count: 27)
SLC1A2 related KEGG pathways (count: 1)
SLC1A2 related BioCarta pathways (count: 0)
SLC1A2 related Reactome pathways (count: 5)
SLC1A2 related interactors from protein-protein interaction data in HPRD (count: 2)