Gene Report

Basic Information

Approved Symbol	SLC1A3
Approved Name	solute carrier family 1 (glial high affinity glutamate transporter), member 3
Symbol Alias	EAAT1, GLAST, EA6
Name Alias	"glutamate transporter variant EAAT1ex9skip"
Location	5p13
Position	chr5:36686372-36688436 (+)
External Links	Entrez Gene: 6507 Ensembl: ENSG00000079215 UCSC: uc003jkj.4 HGNC ID: 10941
No. of Studies (Positive/Negative)	4(3/1)
Type	Literature-origin; Protein mapped

Positive relationships between SLC1A3 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC1A3	Bernard, 2010	patients and normal controls		The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
SLC1A3	Choudary, 2005	patients and normal controls		Microarray analysis of specific areas of cerebral cortex fro...... Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. More...

Positive relationships between SLC1A3 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
excitatory amino acid transporter 1 (EAAT1)		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Garcia-Garcia AL, 2009	animal model		VGLUT1+/- mice showed decreased excitatory amino acid transp...... VGLUT1+/- mice showed decreased excitatory amino acid transporter 1 (EAAT1) More...

Positive relationship network of SLC1A3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC1A3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC1A3	Chandley MJ, 2013	patients and normal controls

Negative relationships between SLC1A3 and other components at different levels (count: 0)

SLC1A3 related SNPs in MK4MDD (count: 0)

SLC1A3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Excitatory amino acid transporter 1	P43003	2(2/0)	Literature-origin

SLC1A3 related GO terms (count: 38)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS
GO:0043197	dendritic spine	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006537	glutamate biosynthetic process	biological process	IEA
GO:0001504	neurotransmitter uptake	biological process	TAS[8647279]
GO:0006811	ion transport	biological process	TAS
GO:0009416	response to light stimulus	biological process	IEA
GO:0005314	high-affinity glutamate transmembrane transporter activity	molecular function	IEA
GO:0016323	basolateral plasma membrane	cellular component	IEA
GO:0021545	cranial nerve development	biological process	IEA
GO:0017153	sodium:dicarboxylate symporter activity	molecular function	IEA
GO:0009611	response to wounding	biological process	IEA
GO:0002230	positive regulation of defense response to virus by host	biological process	IMP[22020285]
GO:0046677	response to antibiotic	biological process	IEA
GO:0043490	malate-aspartate shuttle	biological process	IEA
GO:0048667	cell morphogenesis involved in neuron differentiation	biological process	IEA
GO:0050885	neuromuscular process controlling balance	biological process	IEA
GO:0005743	mitochondrial inner membrane	cellular component	IEA
GO:0051938	L-glutamate import	biological process	IDA[7521911]
GO:0007269	neurotransmitter secretion	biological process	TAS
GO:0009449	gamma-aminobutyric acid biosynthetic process	biological process	IEA
GO:0055085	transmembrane transport	biological process	TAS
GO:0016021	integral component of membrane	cellular component	IEA
GO:0016595	glutamate binding	molecular function	IEA
GO:0043205	fibril	cellular component	IEA
GO:0050806	positive regulation of synaptic transmission	biological process	IEA
GO:0031223	auditory behavior	biological process	IEA
GO:0005313	L-glutamate transmembrane transporter activity	molecular function	IDA[7521911]
GO:0016020	membrane	cellular component	TAS[7521911]
GO:0014047	glutamate secretion	biological process	TAS
GO:0070779	D-aspartate import	biological process	IDA[7521911]
GO:0009986	cell surface	cellular component	IEA
GO:0089711	L-glutamate transmembrane transport	biological process	IDA[7521911]; IEA
GO:0007605	sensory perception of sound	biological process	IEA
GO:0098792	xenophagy	biological process	IMP[22020285]
GO:0005886	plasma membrane	cellular component	TAS
GO:0098779	mitophagy in response to mitochondrial depolarization	biological process	IGI[22020285]
GO:0042493	response to drug	biological process	IEA
GO:0043025	neuronal cell body	cellular component	IEA

SLC1A3 related KEGG pathways (count: 0)

SLC1A3 related BioCarta pathways (count: 0)

SLC1A3 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15518	transmembrane transport_of_small_molecules
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...

SLC1A3 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways