Gene Report

Basic Information

Approved Symbol	SLC32A1
Approved Name	solute carrier family 32 (GABA vesicular transporter), member 1
Previous Symbol	VIAAT
Previous Name	vesicular inhibitory amino acid transporter
Symbol Alias	VGAT, bA122O1.1
Location	20q11
Position	chr20:37353105-37358015 (+)
External Links	Entrez Gene: 140679 Ensembl: ENSG00000101438 UCSC: uc002xjc.3 HGNC ID: 11018
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between SLC32A1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC32A1	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between SLC32A1 and other components at different levels (count: 0)

Positive relationship network of SLC32A1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC32A1 and MDD (count: 0)

Negative relationships between SLC32A1 and other components at different levels (count: 0)

SLC32A1 related SNPs in MK4MDD (count: 0)

SLC32A1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Vesicular inhibitory amino acid transporter	Q9H598	1(1/0)	Literature-origin

SLC32A1 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006811	ion transport	biological process	TAS
GO:0055085	transmembrane transport	biological process	TAS
GO:0044292	dendrite terminus	cellular component	IEA
GO:0060077	inhibitory synapse	cellular component	IEA
GO:0044306	neuron projection terminus	cellular component	IDA[12115694]
GO:0007568	aging	biological process	IEA
GO:0030425	dendrite	cellular component	IDA[12115694]
GO:0015187	glycine transmembrane transporter activity	molecular function	IEA
GO:0015495	gamma-aminobutyric acid:hydrogen symporter activity	molecular function	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0030672	synaptic vesicle membrane	cellular component	TAS
GO:0051286	cell tip	cellular component	IEA
GO:0043005	neuron projection	cellular component	IDA[12115694]
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	cellular component	TAS
GO:0044316	cone cell pedicle	cellular component	IEA
GO:0007269	neurotransmitter secretion	biological process	TAS
GO:0005886	plasma membrane	cellular component	TAS

SLC32A1 related KEGG pathways (count: 0)

SLC32A1 related BioCarta pathways (count: 0)

SLC32A1 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_15518	transmembrane transport_of_small_molecules

SLC32A1 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways