MK4MDD

Study Report

Reference
CitationLi HC, 2007 PubMed
Full InfoLi HC, Chen QZ, Qian L. [Chronic mild stress stimulates nitric oxide production in rat brain cortex and hippocampus]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2007; 36(2): 150-154.

Study
Hypothesis or Background To evaluate the nitric oxide (NO) levels in rat brain cortex and hippocampus after chronic mild stress
Sample Informationmale Sprague-Dawley rats
Method DetailSixteen male Sprague-Dawley rats were allocated into control group and model group randomly. Model rats were induced by consecutive chronic mild stress; weight gain, open field test and sucrose solution consumption were investigated before and after procedure. Nitric oxide contents in prefrontal cortex and hippocampus were determined by spectrophotometric assays.
Method Keywordschronic mild stress (CMS); open field test; sucrose consumption test; spectrophotometric analysis
ResultNitric oxide contents in prefrontal cortex and hippocampus were significantly higher in chronic mild stress group. Decreased locomotion, loss of interest and anhedonia were observed in chronic mild stress rat model group. Nitric oxide contents in prefrontal cortex and hippocampus were significantly higher in chronic mild stress group [(31.00 +/-2.55)nmol/mg.pro and (38.11 +/-1.73)nmol/mg.pro, respectively] than those in control group [(26.97 +/-1.38)nmol/mg.pro and (36.06 +/-0.87)nmol/mg.pro, respectively] (P <0.05).

Relationships reported by Li HC, 2007