|Citation||Li HC, 2007 PubMed
|Full Info||Li HC, Chen QZ, Qian L. [Chronic mild stress stimulates nitric oxide production in rat brain cortex and hippocampus]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2007; 36(2): 150-154.
|Hypothesis or Background
To evaluate the nitric oxide (NO) levels in rat brain cortex and hippocampus after chronic mild stress
|Sample Information||male Sprague-Dawley rats |
|Method Detail||Sixteen male Sprague-Dawley rats were allocated into control group and model group randomly. Model rats were induced by consecutive chronic mild stress; weight gain, open field test and sucrose solution consumption were investigated before and after procedure. Nitric oxide contents in prefrontal cortex and hippocampus were determined by spectrophotometric assays.
|Method Keywords||chronic mild stress (CMS); open field test; sucrose consumption test; spectrophotometric analysis
|Result||Nitric oxide contents in prefrontal cortex and hippocampus were significantly higher in chronic mild stress group. Decreased locomotion, loss of interest and anhedonia were observed in chronic mild stress rat model group. Nitric oxide contents in prefrontal cortex and hippocampus were significantly higher in chronic mild stress group [(31.00 +/-2.55)nmol/mg.pro and (38.11 +/-1.73)nmol/mg.pro, respectively] than those in control group [(26.97 +/-1.38)nmol/mg.pro and (36.06 +/-0.87)nmol/mg.pro, respectively] (P <0.05).
Relationships reported by Li HC, 2007