Gene Report

Basic Information

Approved Symbol	GAD2
Approved Name	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Previous Name	glutamate decarboxylase 2 (pancreatic islets and brain, 65kD)
Symbol Alias	GAD65
Location	10p13-p11.2
Position	chr10:26505236-26593491 (+)
External Links	Entrez Gene: 2572 Ensembl: ENSG00000136750 UCSC: uc001isp.2 HGNC ID: 4093
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between GAD2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GAD2	Unschuld, 2009	patients and normal controls		The associated SNPs lie within a 16KB linkage disequilibrium...... The associated SNPs lie within a 16KB linkage disequilibrium-block, including putative 5' GAD2-promoter-elements as well as the 3' end of the gene MYO3A. More...

Positive relationships between GAD2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
GAD65		Stress(stress)	environment	Elizalde N, 2010	animal model		CMS downregulated the GAD65 and VGLUT1 expressions CMS downregulated the GAD65 and VGLUT1 expressions

Positive relationship network of GAD2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GAD2 and MDD (count: 0)

Negative relationships between GAD2 and other components at different levels (count: 0)

GAD2 related SNPs in MK4MDD (count: 0)

GAD2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Glutamate decarboxylase 2	Q05329	2(2/0)	Literature-origin

GAD2 related GO terms (count: 20)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0004351	glutamate decarboxylase activity	molecular function	IEA
GO:0030054	cell junction	cellular component	IEA
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	TAS
GO:0006540	glutamate decarboxylation to succinate	biological process	IEA
GO:0007269	neurotransmitter secretion	biological process	TAS
GO:0030424	axon	cellular component	IEA
GO:0042136	neurotransmitter biosynthetic process	biological process	IEA
GO:0042493	response to drug	biological process	IEA
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	cellular component	TAS
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0030672	synaptic vesicle membrane	cellular component	IEA
GO:0005829	cytosol	cellular component	IEA
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0016595	glutamate binding	molecular function	IEA
GO:0000139	Golgi membrane	cellular component	IEA
GO:0030170	pyridoxal phosphate binding	molecular function	IEA
GO:0031225	anchored to membrane	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI[10671565]
GO:0042734	presynaptic membrane	cellular component	IEA

GAD2 related KEGG pathways (count: 5)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04940	type i_diabetes_mellitus	Type I diabetes mellitus	Type I diabetes mellitus is a disease that results from auto...... Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma). Type I diabetes is a polygenic disease. One of the principle determining genetic factors in diabetes incidence is the inheritance of mutant MHC-II alleles. Another plausible candidate gene is the insulin gene. More...

ID	Name	Brief Description
Gene mapped KEGG pathways
hsa00430	taurine and_hypotaurine_metabolism	Taurine and hypotaurine metabolism
hsa00250	alanine aspartate_and_glutamate_metabolism	Alanine, aspartate and glutamate metabolism
hsa00410	beta alanine_metabolism	beta-Alanine metabolism
hsa00650	butanoate metabolism	Butanoate metabolism

GAD2 related BioCarta pathways (count: 0)

GAD2 related Reactome pathways (count: 0)

GAD2 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GAD2	GAD1	Yes	in vivo	7836456
GAD2	F10	No	in vitro;in vivo	14576464
GAD2	PRKCE	No	in vitro	15147202

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways