MK4MDD

Gene Report

Basic Information
Approved Symbol GAD1
Approved Name glutamate decarboxylase 1 (brain, 67kDa)
Previous Symbol GAD
Previous Name "glutamate decarboxylase 1 (brain, 67kD)"
Location 2q31
Position chr2:171716393-171717661 (+)
External Links Entrez Gene: 2571
Ensembl: ENSG00000128683
UCSC: uc002ugi.3
HGNC ID: 4092
No. of Studies (Positive/Negative) 3(2/1) Help
Type Literature-origin; Protein mapped

Positive relationships between GAD1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GAD1 Hettema, 2006 patients and normal controls P-value=0.003; OR=1.23 Several of the six single-nucleotide polymorphisms tested in...... Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages, and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0.003) with effect size OR=1.23 More...
GAD1 Oh DH, 2014 patients and normal controls P-value=0.045 We found two datasets where the mRNA levels of GAD1 and SLC1...... We found two datasets where the mRNA levels of GAD1 and SLC1A2 in subregions of the dlPFC were significantly and marginally lower in subjects with MDD (n = 15) than in controls (n = 15) (p = 0.045 and 0.057, respectively) More...

Positive relationships between GAD1 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of GAD1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GAD1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
GAD67 Lappalainen J, 2004 Patients and nomal controls Comparison of SNP and haplotype frequencies between individ...... Comparison of SNP and haplotype frequencies between individuals with depression and controls revealed no differences More...

Negative relationships between GAD1 and other components at different levels (count: 0) Help
GAD1 related SNPs in MK4MDD (count: 0)
GAD1 related proteins in MK4MDD (count: 1)
GAD1 related GO terms (count: 19)
GAD1 related KEGG pathways (count: 5)
GAD1 related BioCarta pathways (count: 1)
GAD1 related Reactome pathways (count: 0)
GAD1 related interactors from protein-protein interaction data in HPRD (count: 5)