Pathway Report

Name	cytoskeleton
GO Link	ID: GO:0005856 Name: cytoskeleton Type: cellular component
Description	Genes annotated by the GO term GO:0005856. Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Cytoskeleton		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
Cytoskeleton		Stress(stress)	environment	Tordera RM, 2011	animal model		After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
SEPT4	septin 4	Literature-origin	1(1/0)
VIM	vimentin	Literature-origin; Protein mapped	1(1/0)
RDX	radixin	Literature-origin	1(1/0)
PLEKHH1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	Literature-origin	1(1/0)
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	Literature-origin	1(1/0)
MSN	moesin	Literature-origin	1(1/0)
ABI1	abl-interactor 1	Literature-origin	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
PCLO	piccolo presynaptic cytomatrix protein	Literature-origin; SNP mapped; Protein mapped	1(1/0)
MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2	Literature-origin	1(1/0)
SYMPK	symplekin	Literature-origin	1(1/0)
ELMOD1	ELMO/CED-12 domain containing 1	Literature-origin	1(1/0)
RHOA	ras homolog family member A	Literature-origin	1(1/0)
SYNE1	spectrin repeat containing, nuclear envelope 1	Literature-origin	1(1/0)
CALD1	caldesmon 1	Literature-origin	1(1/0)