Gene Report

Basic Information

Approved Symbol	SYMPK
Approved Name	symplekin
Symbol Alias	SYM, SPK
Location	19q13.3
Position	chr19:46366316-46366423 (-)
External Links	Entrez Gene: 8189 Ensembl: ENSG00000125755 UCSC: uc002pdn.3 HGNC ID: 22935
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SYMPK and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Symplekin	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between SYMPK and other components at different levels (count: 0)

Positive relationship network of SYMPK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SYMPK and MDD (count: 0)

Negative relationships between SYMPK and other components at different levels (count: 0)

SYMPK related SNPs in MK4MDD (count: 0)

SYMPK related proteins in MK4MDD (count: 0)

SYMPK related GO terms (count: 9)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005654	nucleoplasm	cellular component	IDA[8769423]
GO:0006378	mRNA polyadenylation	biological process	IMP[20861839]
GO:0007155	cell adhesion	biological process	IEA
GO:0035307	positive regulation of protein dephosphorylation	biological process	IDA[20861839]
GO:0005886	plasma membrane	cellular component	IDA
GO:0005515	protein binding	molecular function	IPI[18688255\|26496610]
GO:0005923	bicellular tight junction	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA[8769423]

SYMPK related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04530	tight junction	Tight junction	Epithelial tight junctions (TJs) are composed of at least th...... Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

SYMPK related BioCarta pathways (count: 0)

SYMPK related Reactome pathways (count: 0)

SYMPK related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SYMPK	CSTF2	No	in vitro	10669729
SYMPK	HTT	No	yeast 2-hybrid	9700202
SYMPK	HSF1	No	in vitro;yeast 2-hybrid	14707147

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways