Gene Report

Basic Information

Approved Symbol	MSN
Approved Name	moesin
Location	Xq11.1
Position	chrX:64887511-64961793 (+)
External Links	Entrez Gene: 4478 Ensembl: ENSG00000147065 UCSC: uc004dwf.3 HGNC ID: 7373
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MSN and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MSN	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between MSN and other components at different levels (count: 0)

Positive relationship network of MSN in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MSN and MDD (count: 0)

Negative relationships between MSN and other components at different levels (count: 0)

MSN related SNPs in MK4MDD (count: 0)

MSN related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Moesin	P26038	0(0/0)	Gene mapped

MSN related GO terms (count: 26)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	TAS[16130169]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031528	microvillus membrane	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0007159	leukocyte cell-cell adhesion	biological process	IEP[12082081]
GO:0022614	membrane to membrane docking	biological process	IEP[12082081]
GO:0016324	apical plasma membrane	cellular component	IEA
GO:0050839	cell adhesion molecule binding	molecular function	IPI[12082081]
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[1924289]
GO:0045177	apical part of cell	cellular component	IDA[12082081]
GO:0005730	nucleolus	cellular component	IDA
GO:0030175	filopodium	cellular component	IDA[12082081]
GO:0070062	extracellular vesicular exosome	cellular component	IDA
GO:0005902	microvillus	cellular component	IDA[12082081]
GO:0019901	protein kinase binding	molecular function	IPI[19255442]
GO:0005925	focal adhesion	cellular component	IDA
GO:0005515	protein binding	molecular function	IPI
GO:0005634	nucleus	cellular component	IDA
GO:0005102	receptor binding	molecular function	IPI[15819698]
GO:0005886	plasma membrane	cellular component	IDA
GO:0016323	basolateral plasma membrane	cellular component	IEA
GO:0019898	extrinsic to membrane	cellular component	IEA
GO:0006928	cellular component movement	biological process	TAS[16130169]
GO:0008092	cytoskeletal protein binding	molecular function	IEA
GO:0050900	leukocyte migration	biological process	IEP[12082081]
GO:0001931	uropod	cellular component	IEA
GO:2000401	regulation of lymphocyte migration	biological process	IMP[19255442]

MSN related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04810	regulation of_actin_cytoskeleton	Regulation of actin cytoskeleton

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04670	leukocyte transendothelial_migration	Leukocyte transendothelial migration	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the endothelial passage through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...

MSN related BioCarta pathways (count: 0)

MSN related Reactome pathways (count: 0)

MSN related interactors from protein-protein interaction data in HPRD (count: 22)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MSN	SLC9A3R1	No	in vitro;in vivo;yeast 2-hybrid	9430655 , 15020681
MSN	MSN	Yes	in vitro	10847681
MSN	PLEC1	No	in vivo	11441066
MSN	ROCK1	No	in vitro	9516463 , 9856983
MSN	TSC1	No	in vivo;yeast 2-hybrid	12226091
MSN	SELL	No	in vitro	11706008
MSN	SELPLG	No	in vitro;in vivo	12115638
MSN	ICAM3	No	in vitro;in vivo	9298994 , 11784723
MSN	NCF4	No	in vitro;in vivo	11716484
MSN	L1CAM	No	in vivo	12070130
MSN	EZR	No	in vitro;in vivo	7579708 , 8248180
MSN	PPM1B	No	in vitro	10480873
MSN	ICAM1	No	in vitro;in vivo	12082081
MSN	ICAM2	No	in vitro;in vivo	9472040
MSN	CD46	Yes	in vitro;in vivo	7884872 , 12082081
MSN	SPN	No	in vitro;in vivo	9616160
MSN	BCAP31	No	in vivo	12594175
MSN	NCF1	No	in vitro;in vivo	10436021 , 11716484
MSN	CD93	No	in vitro	15819698
MSN	PPM1A	Yes	in vitro	10480873
MSN	VCAM1	No	in vitro;in vivo	7884872 , 12082081
MSN	PRKCQ	Yes	in vitro	9516463 , 9856983

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways