Gene Report

Basic Information

Approved Symbol	CD46
Approved Name	CD46 molecule, complement regulatory protein
Previous Symbol	MIC10, MCP
Previous Name	"antigen identified by monoclonal antibody TRA-2-10", "membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)", "CD46 antigen, complement regulatory protein"
Symbol Alias	TRA2.10, MGC26544, TLX
Location	1q32
Position	chr1:207966941-207968861 (+)
External Links	Entrez Gene: 4179 Ensembl: ENSG00000117335 UCSC: uc001hgj.3 HGNC ID: 6953
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CD46 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CD46 antigen, complement regulatory protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between CD46 and other components at different levels (count: 0)

Positive relationship network of CD46 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CD46 and MDD (count: 0)

Negative relationships between CD46 and other components at different levels (count: 0)

CD46 related SNPs in MK4MDD (count: 0)

CD46 related proteins in MK4MDD (count: 0)

CD46 related GO terms (count: 35)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007338	single fertilization	biological process	IEA
GO:0002079	inner acrosomal membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	IDA[20534589]; TAS
GO:0006508	proteolysis	biological process	IEA
GO:0004175	endopeptidase activity	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[23086448]
GO:0010628	positive regulation of gene expression	biological process	IMP[23086448]
GO:0043382	positive regulation of memory T cell differentiation	biological process	IDA[12540904]
GO:0071636	positive regulation of transforming growth factor beta production	biological process	IDA[12540904]
GO:0001848	complement binding	molecular function	IEA
GO:0045296	cadherin binding	molecular function	IPI[23086448]
GO:0045087	innate immune response	biological process	TAS
GO:0042102	positive regulation of T cell proliferation	biological process	IDA[12540904]
GO:0001618	virus receptor activity	molecular function	IEA
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0035581	sequestering of extracellular ligand from receptor	biological process	IDA[23086448]
GO:0032613	interleukin-10 production	biological process	IDA[23086448]
GO:0070062	extracellular exosome	cellular component	IDA[20458337]
GO:0046718	viral entry into host cell	biological process	IEA
GO:0043086	negative regulation of catalytic activity	biological process	IEA
GO:0010629	negative regulation of gene expression	biological process	IDA[23086448]
GO:0016323	basolateral plasma membrane	cellular component	IEA
GO:0004872	receptor activity	molecular function	TAS[8402913]
GO:0009986	cell surface	cellular component	IDA[23086448]
GO:0002250	adaptive immune response	biological process	IC[12540904]
GO:0045591	positive regulation of regulatory T cell differentiation	biological process	IDA[12540904]
GO:0006958	complement activation, classical pathway	biological process	IEA
GO:0032733	positive regulation of interleukin-10 production	biological process	IDA[12540904]
GO:0008593	regulation of Notch signaling pathway	biological process	IDA[23086448]
GO:0045916	negative regulation of complement activation	biological process	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[1711570]
GO:0030449	regulation of complement activation	biological process	TAS
GO:0004857	enzyme inhibitor activity	molecular function	IEA
GO:0002456	T cell mediated immunity	biological process	IMP[23086448]
GO:0005925	focal adhesion	cellular component	IDA[21423176]

CD46 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04610	complement and_coagulation_cascades	Complement and coagulation cascades	Blood coagulation is a series of coordinated and calcium-dep...... Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. More...

CD46 related BioCarta pathways (count: 0)

CD46 related Reactome pathways (count: 0)

CD46 related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CD46	ITGB1	No	in vivo	10741407
CD46	DLG4	Yes	in vivo;yeast 2-hybrid	11714708
CD46	SRC	No	in vitro	10657632
CD46	LLGL1	No	in vitro;yeast 2-hybrid	11714708
CD46	C3	No	in vitro	1717583
CD46	C4B	No	in vitro	1717583
CD46	TSPAN4	No	in vivo	10741407
CD46	MSN	Yes	in vitro;in vivo	7884872 , 12082081
CD46	YES1	No	in vivo	11901164
CD46	CD46	Yes	in vitro	10357804

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways