Gene Report

Basic Information

Approved Symbol	ABI1
Approved Name	abl-interactor 1
Previous Symbol	SSH3BP1
Previous Name	"spectrin SH3 domain binding protein 1"
Symbol Alias	E3B1, ABI-1
Location	10p12.1
Position	chr10:27149793-27149831 (-)
External Links	Entrez Gene: 10006 Ensembl: ENSG00000136754 UCSC: uc001isx.3 HGNC ID: 11320
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ABI1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
abl-interactor 1	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between ABI1 and other components at different levels (count: 0)

Positive relationship network of ABI1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ABI1 and MDD (count: 0)

Negative relationships between ABI1 and other components at different levels (count: 0)

ABI1 related SNPs in MK4MDD (count: 0)

ABI1 related proteins in MK4MDD (count: 0)

ABI1 related GO terms (count: 31)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	IEA
GO:0014069	postsynaptic density	cellular component	IEA
GO:0030054	cell junction	cellular component	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0070062	extracellular exosome	cellular component	IDA[19056867]
GO:0005783	endoplasmic reticulum	cellular component	TAS[9593709]
GO:0030426	growth cone	cellular component	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS[9010225]
GO:0008154	actin polymerization or depolymerization	biological process	NAS[11516653]
GO:0030296	protein tyrosine kinase activator activity	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[9010225\|9593709\|11418237\|12681507\|15289329\|16417406\|17101133\|17395426\|18328268\|20598684\|21078624\|21320496\|26496610]
GO:0005634	nucleus	cellular component	IEA
GO:0008092	cytoskeletal protein binding	molecular function	TAS[9593709]
GO:0005622	intracellular	cellular component	IDA[17101133]
GO:0045087	innate immune response	biological process	TAS
GO:0072673	lamellipodium morphogenesis	biological process	IEA
GO:0006928	movement of cell or subcellular component	biological process	IDA[11516653]
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS
GO:0061098	positive regulation of protein tyrosine kinase activity	biological process	IEA
GO:0030175	filopodium	cellular component	IDA[11516653]
GO:0035855	megakaryocyte development	biological process	IEA
GO:0032403	protein complex binding	molecular function	IDA[18560548]
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	IDA[17101133]
GO:0016032	viral process	biological process	IEA
GO:0031209	SCAR complex	cellular component	IDA[21107423]
GO:0005829	cytosol	cellular component	TAS
GO:0001756	somitogenesis	biological process	IEA
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9010225]
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	TAS
GO:0030027	lamellipodium	cellular component	IDA[11516653\|17101133]

ABI1 related KEGG pathways (count: 0)

ABI1 related BioCarta pathways (count: 0)

ABI1 related Reactome pathways (count: 0)

ABI1 related interactors from protein-protein interaction data in HPRD (count: 23)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ABI1	VASP	No	in vitro;in vivo	16055720
ABI1	NCK2	No	in vitro	11557983
ABI1	EVL	No	in vitro;in vivo	16055720
ABI1	SPTA1	No	in vitro;in vivo;yeast 2-hybrid	9593709
ABI1	NIN	No	in vitro	15048123
ABI1	SOS1	No	in vitro;in vivo	10499589
ABI1	WASF1	No	in vitro	15048123
ABI1	EPS8L1	No	in vivo	14565974
ABI1	MINK1	No	yeast 2-hybrid	15032605
ABI1	EPS8	Yes	in vitro;in vivo	11099046 , 9010225 , 1049958 , 12127568 , 10499589 , 15289329
ABI1	ABI1	Yes	in vitro	12672821
ABI1	PAK2	No	in vitro	11956071
ABI1	WASF2	No	in vitro;in vivo	15048123 , 16055720 , 17101133
ABI1	CYFIP2	No	in vitro	15048123
ABI1	HSPA8	No	in vitro	15048123
ABI1	ENAH	No	in vitro;in vivo;yeast 2-hybrid	12672821 , 16055720 , 17101133
ABI1	NCK1	No	yeast 2-hybrid	11418237
ABI1	NEB	No	in vitro	15048123
ABI1	NCKAP1	No	in vitro;yeast 2-hybrid	15048123 , 11418237 , 16055720
ABI1	ABL1	No	in vitro;in vivo;yeast 2-hybrid	8943360 , 9010225 , 12672821 , 11418237 , 9593709 , 17101133
ABI1	SPTAN1	No	in vitro;yeast 2-hybrid	9593709
ABI1	SOS2	No	in vivo	11003655
ABI1	NCF1	No	in vitro;yeast 2-hybrid	12681507

Gene Report

Literature-origin GO terms

Gene mapped GO terms