Gene Report

Basic Information

Approved Symbol	EPS8
Approved Name	epidermal growth factor receptor pathway substrate 8
Location	12p12.3
Position	chr12:15942095-15942510 (-)
External Links	Entrez Gene: 2059 Ensembl: ENSG00000151491 UCSC: uc001rdb.3 HGNC ID: 3420
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between EPS8 and MDD (count: 0)

Positive relationships between EPS8 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Eps8		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of EPS8 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between EPS8 and MDD (count: 0)

Negative relationships between EPS8 and other components at different levels (count: 0)

EPS8 related SNPs in MK4MDD (count: 0)

EPS8 related proteins in MK4MDD (count: 0)

EPS8 related GO terms (count: 30)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0014069	postsynaptic density	cellular component	IEA
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0032420	stereocilium	cellular component	ISS
GO:0017146	NMDA selective glutamate receptor complex	cellular component	IEA
GO:0032587	ruffle membrane	cellular component	ISS
GO:0048149	behavioral response to ethanol	biological process	IEA
GO:0070358	actin polymerization-dependent cell motility	biological process	ISS
GO:0031532	actin cytoskeleton reorganization	biological process	IEA
GO:0036336	dendritic cell migration	biological process	ISS
GO:0010458	exit from mitosis	biological process	ISS
GO:0005070	SH3/SH2 adaptor activity	molecular function	TAS[8084614]
GO:0030426	growth cone	cellular component	IEA
GO:0030832	regulation of actin filament length	biological process	ISS
GO:0009967	positive regulation of signal transduction	biological process	IEA; TAS[8084614]
GO:0048365	Rac GTPase binding	molecular function	ISS
GO:0051764	actin crosslink formation	biological process	ISS
GO:0008344	adult locomotory behavior	biological process	IEA
GO:0031982	vesicle	cellular component	IDA[19190083]
GO:0016601	Rac protein signal transduction	biological process	ISS
GO:0005938	cell cortex	cellular component	ISS
GO:0008360	regulation of cell shape	biological process	ISS
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS[8084614]
GO:0008283	cell proliferation	biological process	TAS[8084614]
GO:0005515	protein binding	molecular function	IPI[15289329\|16189514\|16688213\|21988832\|24658140\|25416956\|25814554]
GO:0051017	actin filament bundle assembly	biological process	ISS
GO:0051016	barbed-end actin filament capping	biological process	ISS
GO:0005903	brush border	cellular component	IEA
GO:0003779	actin binding	molecular function	ISS
GO:0007165	signal transduction	biological process	TAS[8084614]
GO:0070062	extracellular exosome	cellular component	IDA[11487543\|19056867\|23376485\|23533145]

EPS8 related KEGG pathways (count: 0)

EPS8 related BioCarta pathways (count: 0)

EPS8 related Reactome pathways (count: 0)

EPS8 related interactors from protein-protein interaction data in HPRD (count: 24)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
EPS8	SOS1	No	in vitro	10499589
EPS8	ITGB3	No	in vitro	12606711
EPS8	CASK	No	in vitro;in vivo	16688213
EPS8	HOOK2	No	yeast 2-hybrid	16189514
EPS8	DVL1	No	in vitro;yeast 2-hybrid	10581192
EPS8	TEX28	No	yeast 2-hybrid	16189514
EPS8	SHB	No	in vitro;in vivo	7537362
EPS8	ITGB1	No	in vitro	12606711
EPS8	PLDN	No	yeast 2-hybrid	16189514
EPS8	BAIAP2	No	in vivo	15289329
EPS8	USP6NL	No	in vivo	11099046 , 8700527
EPS8	CCDC85B	No	yeast 2-hybrid	16189514
EPS8	EPS8	Yes	in vitro;in vivo;yeast 2-hybrid	8700515 , 9303002 , 10499589 , 9010225 , 16189514
EPS8	EGFR	No	in vivo	7532293 , 12127568
EPS8	ABI1	Yes	in vitro;in vivo	11099046 , 9010225 , 1049958 , 12127568 , 10499589 , 15289329
EPS8	SRC	No	in vitro;in vivo	10395945
EPS8	DNALI1	No	yeast 2-hybrid	16169070
EPS8	SHC1	No	in vitro;in vivo	7791787
EPS8	MYO15A	No	yeast 2-hybrid	16169070
EPS8	ACTA1	No	in vivo	11524436 , 12127568
EPS8	PCM1	Yes	yeast 2-hybrid	16189514
EPS8	AIMP2	No	yeast 2-hybrid	16189514
EPS8	MRPL20	No	yeast 2-hybrid	16169070
EPS8	ITGB5	Yes	in vitro	12606711

Gene Report

Literature-origin GO terms

Gene mapped GO terms