Gene Report

Basic Information

Approved Symbol	CALD1
Approved Name	caldesmon 1
Symbol Alias	CDM, H-CAD, L-CAD
Location	7q33
Position	chr7:134653097-134655392 (+)
External Links	Entrez Gene: 800 Ensembl: ENSG00000122786 UCSC: uc003vrz.3 HGNC ID: 1441
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CALD1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CALD1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between CALD1 and other components at different levels (count: 0)

Positive relationship network of CALD1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CALD1 and MDD (count: 0)

Negative relationships between CALD1 and other components at different levels (count: 0)

CALD1 related SNPs in MK4MDD (count: 0)

CALD1 related proteins in MK4MDD (count: 0)

CALD1 related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	TAS[16130169]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0017022	myosin binding	molecular function	IEA
GO:0006928	movement of cell or subcellular component	biological process	TAS[16130169]
GO:0030478	actin cap	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0005515	protein binding	molecular function	IPI[21044950]
GO:0005886	plasma membrane	cellular component	IDA
GO:0030016	myofibril	cellular component	IEA
GO:0005523	tropomyosin binding	molecular function	TAS[1555769]
GO:0005516	calmodulin binding	molecular function	IEA
GO:0003779	actin binding	molecular function	IEA
GO:0015629	actin cytoskeleton	cellular component	IDA
GO:0006936	muscle contraction	biological process	TAS

CALD1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04270	vascular smooth_muscle_contraction	Vascular smooth muscle contraction	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration (c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase c in VSMCs. The increase in c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement. The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

CALD1 related BioCarta pathways (count: 0)

CALD1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_17044	muscle contraction
REACT_20558	smooth muscle_contraction	Layers of smooth muscle cells can be found in the walls of n...... Layers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac muscle. Smooth muscle is triggered to contract by the autonomic nervous system, hormones, autocrine/paracrine agents, local chemical signals, and changes in load or length. Actin:myosin cross bridging is used to develop force with the influx of calcium ions (Ca2+) initiating contraction. Two separate protein pathways, both triggered by calcium influx contribute to contraction, a calmodulin driven kinase pathway, and a caldesmon driven pathway. Recent evidence suggests that actin, myosin, and intermediate filaments may be far more volatile then previously suspected, and that changes in these cytoskeletal elements along with alterations of the focal adhesions that anchor these proteins may contribute to the contractile cycle. Contraction in smooth muscle generally uses a variant of the same sliding filament model found in striated muscle, except in smooth muscle the actin and myosin filaments are anchored to focal adhesions, and dense bodies, spread over the surface of the smooth muscle cell. When actin and myosin move across one another focal adhesions are drawn towards dense bodies, effectively squeezing the cell into a smaller conformation. The sliding is triggered by calcium:caldesmon binding, caldesmon acting in an analogous fashion to troponin in striated muscle. Phosphorylation of myosin light chains also is involved in the initiation of an effective contraction. More...

CALD1 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CALD1	SHC1	No	in vitro	10559276
CALD1	CALM1	Yes	in vitro	9003189 , 11736632
CALD1	CALM2	Yes	in vivo	11736632
CALD1	GRB2	No	in vitro	10559276
CALD1	CALM3	No	in vivo	11736632
CALD1	CDK1	No	in vitro	12613668

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways