MK4MDD

Gene Report

Basic Information
Approved Symbol PCLO
Approved Name piccolo presynaptic cytomatrix protein
Previous Name "piccolo (presynaptic cytomatrix protein)"
Symbol Alias KIAA0559, DKFZp779G1236, ACZ
Name Alias "aczonin"
Location 7q11.23-q21.3
Position chr7:82791909-82792197 (-)
External Links Entrez Gene: 27445
Ensembl: ENSG00000186472
UCSC: uc003uhx.2
HGNC ID: 13406
No. of Studies (Positive/Negative) 1(1/0) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between PCLO and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
PCLO Sullivan, 2009 patients and normal controls P-value<1 E(-5) Of the top 200, 11 signals localized to a 167 kb region over...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More...

Positive relationships between PCLO and other components at different levels (count: 0) Help
Positive relationship network of PCLO in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between PCLO and MDD (count: 0)
Negative relationships between PCLO and other components at different levels (count: 0) Help
PCLO related SNPs in MK4MDD (count: 1)
PCLO related proteins in MK4MDD (count: 1)
PCLO related GO terms (count: 16)
PCLO related KEGG pathways (count: 0)
PCLO related BioCarta pathways (count: 0)
PCLO related Reactome pathways (count: 0)
PCLO related interactors from protein-protein interaction data in HPRD (count: 2)