SNP Report

Name	rs2715148 dbSNP Ensembl
Location	Chrchr7:82450035(Forward)
Variant Alleles	A/C
Ancestral Allele	C
Annotation	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
Consequence to Transcript	3_prime_UTR_variant(ENST00000423517) downstream_gene_variant(ENST00000426442) intron_variant(ENST00000333891, ENST00000432078) nc_transcript_variant(ENST00000432078)
No. of Studies (Positive/Negative)	2 (2/0)

Reference	Research Type	Statistical Result	Relation Description
Sullivan, 2009	patients and normal controls	P-value=7.7E(-7)	Of the top 200, 11 signals localized to a 167 kb region over...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More...
Aragam, 2011	patients and normal controls	P-value=5.64E(-7)	We identified 40 male-specific and 56 female-specific MDD as...... We identified 40 male-specific and 56 female-specific MDD associated SNPs with P-values less than 10(-4). The best male-specific SNP was rs9352774 (P=2.26x10(-6)) within LGSN gene while the best female-specific SNP was rs2715148 (P=5.64x10(-7)) within PCLO gene. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
PCLO	piccolo presynaptic cytomatrix protein	Literature-origin; SNP mapped; Protein mapped	1(1/0)