SNP Report

Name	rs2522833 dbSNP Ensembl
Location	Chrchr7:82453708(Forward)
Variant Alleles	A/C
Ancestral Allele	A
Annotation	missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant PolyPhen: possibly damaging(ENST00000423517) unknown(ENST00000333891)
Consequence to Transcript	missense_variant(ENST00000423517, ENST00000333891) nc_transcript_variant(ENST00000426442) non_coding_exon_variant(ENST00000426442) upstream_gene_variant(ENST00000432078)
No. of Studies (Positive/Negative)	3 (3/0)

Reference	Research Type	Statistical Result	Relation Description
Sullivan, 2009	patients and normal controls	P-value=1.2E(-6)	Of the top 200, 11 signals localized to a 167 kb region over...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More...
Hek K, 2010	Patients and nomal controls		Logistic regression analysis showed an association between r...... Logistic regression analysis showed an association between rs2522833 and depressive disorders (P = 0.0025) More...
Minelli A, 2012	patients and normal controls	P-value<0.01	The results showed that rs2522833 CC homozygotes were more f...... The results showed that rs2522833 CC homozygotes were more frequent among the depressed patients than in the controls (p<0.01) More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
PCLO	piccolo presynaptic cytomatrix protein	Literature-origin; SNP mapped; Protein mapped	1(1/0)