Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
subgenual anterior cingulate (subgenual anterior cingulate cortex (ACC))
|
brain morphology and function |
Progesterone (progesterone) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|
Orbitofrontal cortex (orbitofrontal cortex (OFC))
|
brain morphology and function |
Progesterone (progesterone) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|
MDD
|
syndrome |
Progesterone (progesterone) |
molecule |
|
MDD women had a lower serum estradiol and higher serum progesterone compared to controls. |
Positive
|
MDD
|
syndrome |
Estradiol (estradiol) |
molecule |
|
MDD women had a lower serum estradiol and higher serum progesterone compared to controls. |
Positive
|
MDD
|
syndrome |
Hippocampus (hippocampus) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
MDD
|
syndrome |
Hypothalamus (hypothalamus) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
MDD
|
syndrome |
Amygdala (amygdala) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
MDD
|
syndrome |
Anterior cingulate cortex (anterior cingulate cortex (ACC)) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
Stress (stress)
|
environment |
Hypothalamic-pituitary-gonadal axis (hypothalamic-pituitary-gonadal (HPG)-axis) |
neurobiological system |
|
Hypoactivation of the stress response circuitry in MDD women is associated with dysregulation of the HPG-axis. |
Positive
|
MDD
|
syndrome |
Hypothalamic-pituitary-gonadal axis (hypothalamic-pituitary-gonadal (HPG)-axis) |
neurobiological system |
|
Hypoactivation of the stress response circuitry in MDD women is associated with dysregulation of the HPG-axis. |
Positive
|
MDD
|
syndrome |
Orbitofrontal cortex (orbitofrontal cortex (OFC)) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
MDD
|
syndrome |
subgenual anterior cingulate (subgenual anterior cingulate cortex (ACC)) |
brain morphology and function |
|
fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. |
Positive
|
subgenual anterior cingulate (subgenual anterior cingulate cortex (ACC))
|
brain morphology and function |
Estradiol (estradiol) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|
Hypothalamus (hypothalamus)
|
brain morphology and function |
Progesterone (progesterone) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|
Hypothalamus (hypothalamus)
|
brain morphology and function |
Estradiol (estradiol) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|
Orbitofrontal cortex (orbitofrontal cortex (OFC))
|
brain morphology and function |
Estradiol (estradiol) |
molecule |
|
Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. |
Positive
|