Molecule Report

Name	Estradiol
Description	Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors ( RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.
MeSH ID	D004958
No. of Studies (Positive/Negative)	2(2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
estradiol	Gaiteri, 2010	patients and normal controls	P-value<0.01	Biological networks and signal transduction pathways corresp...... Biological networks and signal transduction pathways corresponding to the identified gene set suggested putative dysregulated functions for several hormone-type factors previously implicated in depression (insulin, interleukin-1, thyroid hormone, estradiol and glucocorticoids; p<0.01 for association with depression-related networks). More...
estradiol	Holsen, 2011	patients and normal controls		MDD women had a lower serum estradiol and higher serum proge...... MDD women had a lower serum estradiol and higher serum progesterone compared to controls. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
estradiol		Hypothalamus(hypothalamus)	brain morphology and function	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
estradiol		Orbitofrontal cortex(orbitofrontal cortex (OFC))	brain morphology and function	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
estradiol		subgenual anterior cingulate(subgenual anterior cingulate cortex (ACC))	brain morphology and function	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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