MK4MDD

Molecule Report

Basic Information
Name Hydrocortisone
Description The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
MeSH ID D006854
No. of Studies (Positive/Negative) 68(67/1) Help

Positive relationship between Hydrocortisone and MDD (count: 42)
Name in Literature Reference Research Type Statistical Result Relation Description Help
cortisol Weizman, 1988 patients and normal controls A blunted response followed by a decrease (33%) in serum cor...... A blunted response followed by a decrease (33%) in serum cortisol levels was observed in depressed patients 5 h after drug (serotonin agonistic agent fenfluramine) administration while an increase of 94% was obtained in controls after 3 h. More...
cortisol Gotthardt, 1995 patients and normal controls Basal hypercortisolemia and, at baseline, heart rates were h...... Basal hypercortisolemia and, at baseline, heart rates were higher in depressed patients. More...
cortisol Yehuda, 1993 patients and normal controls The mean 24-hour urinary cortisol excretion was significantl...... The mean 24-hour urinary cortisol excretion was significantly higher in patients with major depression and bipolar mania than in those in the other diagnostic groups. More...
cortisol Croes, 1993 patients and normal controls cortisol decreased after both controllable and uncontrollabl...... cortisol decreased after both controllable and uncontrollable stress in the acutely depressed group More...
cortisol Levitan, 2002 patients and normal controls P-value < 0.01 After the 0.50-mg dexamethasone challenge, mean suppression ...... After the 0.50-mg dexamethasone challenge, mean suppression of morning cortisol was significantly greater in patients with atypical depression (91.9%, standard deviation [SD] 6.8%) than in the controls (78.3%, SD 10.7%; p < 0.01). More...
cortisol Antonijevic, 2003 patients and normal controls Nocturnal cortisol secretion was increased in postmenopausal...... Nocturnal cortisol secretion was increased in postmenopausal patients with depression, while a decrease was noted in postmenopausal controls. More...
cortisol Jozuka, 2003 patients and normal controls Compared with controls, NK-cell activity and levels of corti...... Compared with controls, NK-cell activity and levels of cortisol and DHEA were reduced in patients with major depression, whereas IL-2 levels were increased. More...
cortisol Mathew, 2003 patients and normal controls Of the subjects who had experienced at least one lifetime ma...... Of the subjects who had experienced at least one lifetime major depressive episode during the follow-up period, the subgroup who would go on to make suicide attempts during the follow-up period secreted significantly greater levels of cortisol in the 4, 6, and 12 h prior to sleep onset. More...
cortisol Sarandol, 2003 patients and normal controls All cortisol responses were found to be significantly higher...... All cortisol responses were found to be significantly higher in the patient group during depression period compared to the control group except at 16:00 before dexamethasone. More...
cortisol Bhagwagar, 2003 patients and normal controls The increase in salivary cortisol levels that followed wakin...... The increase in salivary cortisol levels that followed waking was significantly higher in the patients. More...
cortisol Dinan, 2004 patients and normal controls The mean +/- S.E.M. cortisol response in the depressives was...... The mean +/- S.E.M. cortisol response in the depressives was 261.8 +/- 46.5 nmol/l and in the healthy subjects was 107.3 +/- 26.1 nmol/l (P < 0.01). More...
cortisol Rao, 2004 patients only Compared to the depressed state, NUFC (nocturnal urinary fre...... Compared to the depressed state, NUFC (nocturnal urinary free cortisol ) was significantly lower during remission. More...
cortisol Ferrari, 2004 patients and normal controls The trend towards the increase of the nocturnal cortisol lev...... The trend towards the increase of the nocturnal cortisol levels was also evident in old subjects with major depression. More...
cortisol Posener, 2004 patients and normal controls the depressed men had significantly increased cortisol ApEn ...... the depressed men had significantly increased cortisol ApEn (approximate entropy) and significantly decreased ACTH ApEn compared with the healthy subjects. More...
cortisol Koenigsberg, 2004 patients and normal controls The depressed patients had phase advanced circadian rhythms ...... The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. More...
cortisol O'Brien, 2004 patients and normal controls Depressed subjects had hypercortisolemia (53% increase in ar...... Depressed subjects had hypercortisolemia (53% increase in area under the curve) and a reduction in right hippocampal volume (6% decrease). More...
cortisol Brouwer, 2005 patients and normal controls P-value = 0.01 In atypical depression, serum cortisol was lower than in non...... In atypical depression, serum cortisol was lower than in non-atypical depression (P = 0.01). More...
cortisol Forbes, 2006 patients and normal controls Adolescents with depression had marginally higher peri-sleep...... Adolescents with depression had marginally higher peri-sleep-onset cortisol than control adolescents and significantly higher peri-sleep-onset cortisol than children with depression. More...
cortisol Appelhof, 2006 patients only Posttreatment maximal adrenocorticotropic hormone (ACTH) and...... Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). More...
cortisol Pavon, 2006 patients and normal controls The MDD subjects showed higher levels of cortisol and TNF-al...... The MDD subjects showed higher levels of cortisol and TNF-alpha, More...
cortisol Duval, 2006 patients and normal controls P-value<0.004 Compared with controls, patients showed lower adrenocorticot...... Compared with controls, patients showed lower adrenocorticotropin and cortisol response to apomorphine (p<0.015 and <0.004, respectively) More...
cortisol Young, 2006 high-risk people and normal controls Children with MDD parents showed higher cortisol basally and...... Children with MDD parents showed higher cortisol basally and higher cortisol after both 25 mg and 5 mg dexamethasone. More...
cortisol Kennedy, 2006 patients and normal controls Comparisons between patients with MDD and controls showed si...... Comparisons between patients with MDD and controls showed significantly lower neutral-state mu-opioid receptor BP in patients with MDD in the posterior thalamus, correlating with corticotropin and cortisol plasma levels. More...
cortisol Ising, 2007 patients and normal controls We found increased ACTH and cortisol responses to the first...... We found increased ACTH and cortisol responses to the first DEX/CRH test compared with healthy control subjects. More...
cortisol Bremmer, 2007 patients and normal controls B CORT = -9.50 [SE 3.85] P-value = 0.014; B CORT(2) = 0.008 [SE .003] P-value = 0.021 The association between cortisol and major depression was U-...... The association between cortisol and major depression was U-shaped (B CORT = -9.50 [SE 3.85] p = .014; B CORT(2) = .008 [SE .003] p = .021). More...
cortisol Aihara, 2007 patients only 75% of unmedicated MDD patients exhibited a heightened corti...... 75% of unmedicated MDD patients exhibited a heightened cortisol response to the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. More...
cortisol Heim, 2008 patients and normal controls Men with childhood trauma histories exhibited increases in A...... Men with childhood trauma histories exhibited increases in ACTH and cortisol responses to dexamethasone/CRF compared with non-abused men. In particular, abused men with current MDD showed increased responsiveness compared with control subjects and depressed men without childhood abuse experience More...
cortisol Ahrens, 2008 patients and normal controls Morning saliva cortisol concentrations were lower in remitte...... Morning saliva cortisol concentrations were lower in remitted patients, paralleled by lower serum cortisol concentrations before stress testing. More...
cortisol Rao, 2008 patients and normal controls Compared with control subjects, depressed subjects showed mo...... Compared with control subjects, depressed subjects showed more elevated and prolonged cortisol secretion in response to Trier Social Stress Test (TSST). More...
cortisol Hernandez, 2008 patients and normal controls Before treatment we found high levels of cortisol, IL-4, IL-...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More...
cortisol Rao, 2008 patients and normal controls Compared with controls, depressed adolescents had significan...... Compared with controls, depressed adolescents had significantly elevated NUFC (nocturnal urinary free cortisol) excretion. More...
cortisol Rao, 2009 high-risk people and normal controls Compared with normal controls, adolescents at high risk for ...... Compared with normal controls, adolescents at high risk for depression had shorter latency to rapid eye movement (REM) sleep, increased phasic REM sleep, more REM sleep and elevated nocturnal urinary-free cortisol (NUFC) excretion at baseline. More...
cortisol Vreeburg, 2009 patients and normal controls Evening cortisol levels were higher among the current MDD gr...... Evening cortisol levels were higher among the current MDD group at 10 pm but not at 11 pm. More...
cortisol Hinkelmann, 2009 patients and normal controls Compared with healthy subjects, patients had significantly h...... Compared with healthy subjects, patients had significantly higher cortisol levels and were impaired in verbal memory, visuospatial memory, working memory, and selective attention. More...
cortisol Buckley, 2010 patients and normal controls P-value=0.026 Phase angle (phase angle between cortisol acrophase and dim-...... Phase angle (phase angle between cortisol acrophase and dim-light melatonin onset) was significantly increased in MDD's versus healthy controls (13.40+/-1.61h. versus 11.61+/-1.66h, p=0.026). More...
cortisol Klatzkin, 2010 patients and normal controls only in women with histories of MDD did PMDD women have lowe...... only in women with histories of MDD did PMDD women have lower cortisol concentrations than non-PMDD women More...
cortisol Scharnholz, 2010 patients and normal controls During the acute episode depressed patients showed increased...... During the acute episode depressed patients showed increased levels of night-time cortisol excretion compared to healthy controls. More...
cortisol Cizza, 2010 patients and normal controls In cross-correlation analyses, the relationship between cort...... In cross-correlation analyses, the relationship between corticotropin and cortisol concentrations was stronger in women with MDD than in control subjects, a finding consistent with hypothalamic-pituitary-adrenal (HPA) axis activation in MDD. More...
cortisol Vreeburg, 2010 high-risk people As compared with unaffected participants without parental hi...... As compared with unaffected participants without parental history, unaffected individuals with diagnosed parental history of depression or anxiety showed a significantly higher cortisol awakening curve (effect size (d) = 0.50), which was similar to that observed in the participants with depression or anxiety disorders. More...
cortisol Dedovic, 2010 high-risk people and normal controls The high-risk subclinical group also showed a lower area-und...... The high-risk subclinical group also showed a lower area-under-the-curve increase of cortisol levels after awakening compared with control subjects. More...
cortisol Jabben, 2011 patients and normal controls Unipolar depressive disorder (UP) patients showed a higher i...... Unipolar depressive disorder (UP) patients showed a higher increase over time in the cortisol awakening response (CAR). More...
cortisol Lopes, 2012 patients and normal controls MDD patients with or without previous trauma had similarly l...... MDD patients with or without previous trauma had similarly lower salivary cortisol. More...

Positive relationships between Hydrocortisone and other components at different levels (count: 42) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Hydrocortisone in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationship between Hydrocortisone and MDD (count: 0)
Negative relationships between Hydrocortisone and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment