Study Report
Reference
| Citation | Rao, 2008 PubMed |
| Full Info | Rao, U. and Poland, R.E. (2008) Electroencephalographic sleep and hypothalamic-pituitary-adrenal changes from episode to recovery in depressed adolescents. J Child Adolesc Psychopharmacol, 18, 607-613.
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Study
| Hypothesis or Background |
The study examined electroencephalographic (EEG) sleep and hypothalamic-pituitary-adrenal (HPA) changes associated with depressive episode and during recovery in adolescent depression.
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| Sample Information | Sixteen adolescents with major depressive disorder and 16 volunteers with no personal or family history of psychiatric disorder |
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| Method Detail | All subjects participated in a three-night EEG sleep protocol along with nocturnal urinary free cortisol (NUFC). Depressed subjects also were restudied during stable remission from the depressive episode. |
| Method Keywords | electroencephalogram (EEG); urinary analysis |
| Result | Compared with controls, depressed adolescents had significantly reduced sleep efficiency, shorter latency to rapid eye movement (REM) sleep, increased phasic REM sleep, and elevated NUFC excretion. Among depressed subjects, EEG sleep values did not change significantly from episode to remission. NUFC excretion reduced significantly during remission from the depressive episode. |
| Conclusions | The findings that EEG sleep measures are independent of clinical state, whereas HPA variables are state dependent, suggest that sleep and HPA measures make a differential contribution to our understanding of the pathophysiology and prognosis of mood disorders in adolescent patients. |
Relationships reported by
Rao, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Hypothalamic-pituitary-adrenal axis (hypothalamic-pituitary-adrenal (HPA)) |
neurobiological system |
|
The findings that EEG sleep measures are independent of clinical state, whereas HPA variables are state dependent, suggest that sleep and HPA measures make a differential contribution to our understanding of the pathophysiology and prognosis of mood disorders in adolescent patients. |
Positive
|
|
MDD
|
syndrome |
Hydrocortisone (cortisol) |
molecule |
|
Compared with controls, depressed adolescents had significantly elevated NUFC (nocturnal urinary free cortisol) excretion. |
Positive
|
|
MDD
|
syndrome |
Rapid eye movement (REM) sleep (rapid eye movement (REM) sleep) |
neurobiological system |
|
Compared with controls, depressed adolescents had significantly reduced sleep efficiency, shorter latency to rapid eye movement (REM) sleep, increased phasic REM sleep. The findings that EEG sleep measures are independent of clinical state, whereas HPA variables are state dependent, suggest that sleep and HPA measures make a differential contribution to our understanding of the pathophysiology and prognosis of mood disorders in adolescent patients. |
Positive
|
