Protein Report

Protein Name	Leptin
UniPortKB	P41159
No. of Studies (Positive/Negative)	3 (3/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
leptin	Westling, 2004	patients only	P-value<0.01	women in the MDD group had lower CSF(cerebrospinal fluid) le...... women in the MDD group had lower CSF(cerebrospinal fluid) leptin than those in the non-MDD group (P < 0.01). More...
leptin	Jow, 2006	patients and normal controls		leptin and cholesterol levels were low in patients with majo...... leptin and cholesterol levels were low in patients with major depressive disorder More...
leptin	Cizza, 2010	patients and normal controls		mean nocturnal leptin concentration was higher in the MDD ve...... mean nocturnal leptin concentration was higher in the MDD versus control groups More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
leptin		Adiponectin(adiponectin)	protein	Cizza, 2010	patients and normal controls		Mean leptin concentration was inversely related to cortisol ...... Mean leptin concentration was inversely related to cortisol and adiponectin concentrations, both in subjects with depression and in control subjects. More...
leptin		Hydrocortisone(cortisol)	molecule	Cizza, 2010	patients and normal controls		Mean leptin concentration was inversely related to cortisol ...... Mean leptin concentration was inversely related to cortisol and adiponectin concentrations, both in subjects with depression and in control subjects. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
LEP	leptin	Protein mapped	0 (0/0)