Study Report
Reference
| Citation | Pavon, 2006 PubMed |
| Full Info | Pavon, L., Sandoval-Lopez, G., Eugenia Hernandez, M., Loria, F., Estrada, I., Perez, M., Moreno, J., Avila, U., Leff, P., Anton, B. et al. (2006) Th2 cytokine response in Major Depressive Disorder patients before treatment. J Neuroimmunol, 172, 156-165.
|
Study
| Hypothesis or Background |
In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired.
|
| Sample Information | MDD patients and in non-depressed control group |
|---|
| Method Detail | We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. |
| Method Keywords | immunocytochemical analysis |
| Result | The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts and no significant variations in CD3+CD4+ lymphocyte. Moreover, higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group. |
| Conclusions | Overall, we propose that all these changes could be related to the elevated cortisol levels seen in the MDD patients. Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients. |
Relationships reported by
Pavon, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Interleukin-2 (IL-2) |
protein |
|
Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group |
Positive
|
|
MDD
|
syndrome |
Interleukin-4 (IL-4) |
protein |
|
Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group |
Positive
|
|
MDD
|
syndrome |
Interferon gamma (IFN-gamma) |
protein |
|
Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group |
Positive
|
|
MDD
|
syndrome |
Interleukin-13 (IL-13) |
protein |
|
Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group |
Positive
|
|
MDD
|
syndrome |
Killer Cells, Natural (NK) |
cell |
|
The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts |
Positive
|
|
MDD
|
syndrome |
Hydrocortisone (cortisol) |
molecule |
|
The MDD subjects showed higher levels of cortisol and TNF-alpha, |
Positive
|
|
MDD
|
syndrome |
B-Lymphocytes (B cell) |
cell |
|
The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts |
Positive
|
|
MDD
|
syndrome |
CD8-Positive T-Lymphocytes (CD8+) |
cell |
|
The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts |
Positive
|
|
MDD
|
syndrome |
Tumor necrosis factor (TNF-alpha) |
protein |
|
The MDD subjects showed higher levels of cortisol and TNF-alpha, |
Positive
|
