MK4MDD

Protein Report

Basic Information
Protein Name Interleukin-4
UniPortKB P05112
No. of Studies (Positive/Negative) 8 (6/2) Help
Type Literature-origin
Positive relationship between Interleukin-4 and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL-4 Myint, 2005 patients and normal controls The proportion of patients who showed immunoreactivity to IF...... The proportion of patients who showed immunoreactivity to IFN-gamma and IL-4 in the plasma, and the plasma IFN-gamma/IL-4 ratio, were significantly higher in depressed patients than in controls. More...
IL-4 Pavon, 2006 patients and normal controls Higher levels of IL-4 and IL-13 (Th2) and significantly lowe...... Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group More...
interleukin [IL]-4 Kim, 2007 patients and normal controls At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher and IL-4 were significantly lower in MDD patients. More...
interleukin [IL]-4 Kim, 2008 patients and normal controls P-value<0.005 Both MDD groups, with or without attempted suicide, had sign...... Both MDD groups, with or without attempted suicide, had significantly lower IFN-gamma and IL-4 and higher TGF-beta1 production. HDRS(Hamilton's depression rating scale) scores had significant negative correlations with IL-4 in non-suicidal depression patients (p<0.005) More...
IL-4 Hernandez, 2008 patients and normal controls Before treatment we found high levels of cortisol, IL-4, IL-...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More...
IL-4 Lopes, 2012 patients and normal controls PBMCs of MDD patients produced significantly lower interleuk...... PBMCs of MDD patients produced significantly lower interleukin (IL)-2, IL-4 and tumor necrosis factor-alpha levels when compared to healthy controls. More...

Positive relationships between Interleukin-4 and other components at different levels (count: 0) Help
Positive relationship network of Interleukin-4 in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Interleukin-4 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
IL-4 Farid Hosseini R, 2007 patients and nomal controls We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
interleukin-4 Einvik G, 2012 patients and normal controls Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Negative relationships between Interleukin-4 and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
IL4 interleukin 4 Protein mapped 0 (0/0)