Protein Report

Protein Name	Interleukin-4
UniPortKB	P24394
No. of Studies (Positive/Negative)	8 (6/2)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-4	Myint, 2005	patients and normal controls		The proportion of patients who showed immunoreactivity to IF...... The proportion of patients who showed immunoreactivity to IFN-gamma and IL-4 in the plasma, and the plasma IFN-gamma/IL-4 ratio, were significantly higher in depressed patients than in controls. More...
IL-4	Pavon, 2006	patients and normal controls		Higher levels of IL-4 and IL-13 (Th2) and significantly lowe...... Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group More...
interleukin [IL]-4	Kim, 2007	patients and normal controls		At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher and IL-4 were significantly lower in MDD patients. More...
interleukin [IL]-4	Kim, 2008	patients and normal controls	P-value<0.005	Both MDD groups, with or without attempted suicide, had sign...... Both MDD groups, with or without attempted suicide, had significantly lower IFN-gamma and IL-4 and higher TGF-beta1 production. HDRS(Hamilton's depression rating scale) scores had significant negative correlations with IL-4 in non-suicidal depression patients (p<0.005) More...
IL-4	Hernandez, 2008	patients and normal controls		Before treatment we found high levels of cortisol, IL-4, IL-...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More...
IL-4	Lopes, 2012	patients and normal controls		PBMCs of MDD patients produced significantly lower interleuk...... PBMCs of MDD patients produced significantly lower interleukin (IL)-2, IL-4 and tumor necrosis factor-alpha levels when compared to healthy controls. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-4	Farid Hosseini R, 2007	patients and nomal controls		We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
interleukin-4	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL4	interleukin 4	Protein mapped	0 (0/0)