Protein Report

Protein Name	Interleukin-2
UniPortKB	P60568
No. of Studies (Positive/Negative)	6 (5/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-2	Jozuka, 2003	patients and normal controls		Compared with controls, NK-cell activity and levels of corti...... Compared with controls, NK-cell activity and levels of cortisol and DHEA were reduced in patients with major depression, whereas IL-2 levels were increased. More...
IL-2	Pavon, 2006	patients and normal controls		Higher levels of IL-4 and IL-13 (Th2) and significantly lowe...... Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group More...
interleukin [IL]-2	Kim, 2007	patients and normal controls		At admission IFN-gamma, IL-2, and IL-4 were significantly lo...... At admission IFN-gamma, IL-2, and IL-4 were significantly lower in MDD patients. More...
interleukin [IL]-2	Kim, 2008	patients and normal controls	P-value<0.001	Suicidal MDD patients had significantly lower IL-2 compared ...... Suicidal MDD patients had significantly lower IL-2 compared with non-suicidal patients and normal controls (p<0.001). More...
IL-2	Lopes, 2012	patients and normal controls		PBMCs of MDD patients produced significantly lower interleuk...... PBMCs of MDD patients produced significantly lower interleukin (IL)-2, IL-4 and tumor necrosis factor-alpha levels when compared to healthy controls. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
interleukin [IL]-2		Suicide(suicide)	symptoms	Kim, 2008	patients and normal controls	P-value<0.001	Suicidal MDD patients had significantly lower IL-2 compared ...... Suicidal MDD patients had significantly lower IL-2 compared with non-suicidal patients and normal controls (p<0.001). More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
interleukin-2	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL2	interleukin 2	Literature-origin; Protein mapped	1 (1/0)