Study Report
Reference
| Citation | Gotthardt, 1995 PubMed |
| Full Info | Gotthardt, U., Schweiger, U., Fahrenberg, J., Lauer, C.J., Holsboer, F. and Heuser, I. (1995) Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression. Am J Physiol, 268, R865-873.
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Study
| Hypothesis or Background |
Aging and hypercortisolism may be associated with alterations of stress-induced hormone release.
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| Sample Information | 20 normal controls of two different age groups (< 30 and > 60 yr of age) and 20 age-matched patients with major depression |
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| Method Detail | Baseline ACTH and cortisol secretion (between 1400 and 1700) as well as blood pressure and heart rate and their responses to a 45-min lasting signal detection task (1705-1750) were determined. |
| Method Keywords | cognitive test |
| Result | No difference in basal hypothalamic-pituitary-adrenal (HPA) system activity between young and older healthy controls was noted. The cognitive challenge resulted in an increase in stress-induced hormonal secretion that was greater in the older controls than in their young counterparts. Basal hypercortisolemia and, at baseline, heart rates were higher in depressed patients, regardless of age. Blood pressure was elevated in older healthy controls as well as depressed patients. With the exception of the young depressed patients, all groups responded with an increase of the cardiovascular parameters during stress. |
| Conclusions | No difference in basal hypothalamic-pituitary-adrenal (HPA) system activity between young and older healthy controls was noted. The cognitive challenge resulted in an increase in stress-induced hormonal secretion that was greater in the older controls than in their young counterparts. Basal hypercortisolemia and, at baseline, heart rates were higher in depressed patients, regardless of age. Blood pressure was elevated in older healthy controls as well as depressed patients. With the exception of the young depressed patients, all groups responded with an increase of the cardiovascular parameters during stress. |
Relationships reported by
Gotthardt, 1995
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Heart rate (HR) (heart rates) |
signs |
|
Basal hypercortisolemia and, at baseline, heart rates were higher in depressed patients. |
Positive
|
|
MDD
|
syndrome |
Hydrocortisone (cortisol) |
molecule |
|
Basal hypercortisolemia and, at baseline, heart rates were higher in depressed patients. |
Positive
|
