MK4MDD

Gene Report

Basic Information
Approved Symbol COMT
Approved Name catechol-O-methyltransferase
Location 22q11.21
Position chr22:19956260-19956552 (+)
External Links Entrez Gene: 1312
Ensembl: ENSG00000093010
UCSC: uc002zqu.3
HGNC ID: 2228
No. of Studies (Positive/Negative) 11(8/3) Help
Type Literature-origin; SNP mapped

Positive relationships between COMT and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
COMT Kocabas, 2010 patients and normal controls P-value<0.01 The combinations of G-T-G-G haplotype for rs6269, rs4633, rs...... The combinations of G-T-G-G haplotype for rs6269, rs4633, rs4818 and rs4680 were only present in the MDD group (G-T 4.5%, corrected sim P=0.0001; G-T-G 3.87%, corrected sim P=0.001; G-T-G-G 3.3% corrected sim P=0.0025). More...
COMT Mandelli L, 2007 Patients and nomal controls chi2=13.05, d.f.=2, p=0.0015 COMT was associated with depression following exposure to s...... COMT was associated with depression following exposure to stressors (chi2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (chi2=6.70, d.f.=2, p=0.035), mainly among women and among major depressives. The interaction between COMT and SERTPR was also significant (p=0.0005). More...
COMT Aberg E, 2011 Patients and nomal controls OR=1.49, CI(95%)=1.11-2.00, P=0.009 Depressed individuals displayed a higher frequency of the Me...... Depressed individuals displayed a higher frequency of the Met/Met and Met/Val genotypes compared to controls (OR=1.49, CI(95%)=1.11-2.00, P=0.009). More...
COMT Shen, 2014 Patients and nomal controls OR=1.52, CI95%=1.04¨C2.21, P=0.02 The COMT Met/Val genotype was more common among depressed in...... The COMT Met/Val genotype was more common among depressed individuals than among controls (OR=1.52, CI95%=1.04¨C2.21, P=0.02). More...
COMT Gabriela Nielsen, 2015 Patients and nomal controls F=4.81; p=0.03 Regarding the COMT Val158Met polymorphism, we found a differ...... Regarding the COMT Val158Met polymorphism, we found a difference in the genotype distribution between MDD patients and controls (F=4.81; p=0.03). The frequency of Met/Met homozygotes was higher in patients, whereas the Val/Val genotype was more common in healthy subjects More...

Positive relationships between COMT and other components at different levels (count: 9) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of COMT in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between COMT and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
COMT Pandolfo, 2015 Patients and nomal controls P values (COMT Val/Val158)=0.794; P-value (COMT Val/Met158)= 0.471;P-value (COMT Met/Met158)= 0.256 The Val/Met158 genotypewas the most represented in all three...... The Val/Met158 genotypewas the most represented in all three groups, with higher frequencies in MDD and BD patients than in controls, while the Met/Met158 mutated genotype was more frequent in healthy subjects than in patients. However, these differences did not reach statistically significant values. Allele and genotype frequencies of the C1886G (Leu136Leu) variant of the COMT gene in MDD as well as BD patients and healthy subjects are shown in Table 2. Genotype distributions were in the Hardy¨CWeinberg equilibrium both in patients and healthy subjects.The C1886 major allele was the most represented in all groups, accounting for more than 50% of recruited subjects in each group, and its frequency was significantly higher in healthy subjects than in both groups of patients (p<0.05). More...

Negative relationships between COMT and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


COMT related SNPs in MK4MDD (count: 1)
COMT related proteins in MK4MDD (count: 0)
COMT related GO terms (count: 37)
COMT related KEGG pathways (count: 2)
COMT related BioCarta pathways (count: 0)
COMT related Reactome pathways (count: 3)
COMT related interactors from protein-protein interaction data in HPRD (count: 4)