MK4MDD

Gene Report

Basic Information
Approved Symbol ACE
Approved Name angiotensin I converting enzyme
Previous Symbol DCP1
Previous Name "angiotensin I converting enzyme (peptidyl-dipeptidase A) 1"
Symbol Alias ACE1, CD143
Name Alias "peptidyl-dipeptidase A"
Location 17q23.3
Position chr17:61574728-61575741 (+)
External Links Entrez Gene: 1636
Ensembl: ENSG00000159640
UCSC: uc002jau.2
HGNC ID: 2707
No. of Studies (Positive/Negative) 7(6/1) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between ACE and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
ACE Bondy B, 2002 Patients and nomal controls chi(2) = 6.43; df=3; P = 0.04 We found a significant increase in the Gbeta3 T allele (OR ...... We found a significant increase in the Gbeta3 T allele (OR = 1.61, 95% CI 1.17-2.2, P = 0.0035) and a marginal altered genotype distribution of the ACE ID polymorphism with decrease in the II genotypes (chi(2) = 6.43, df=3, P = 0.04) in the patients' group. Analysing the data for both genes we found that the combined actions of ACE and Gbeta3 genotypes accumulate in carriers of the ACE D allele (ID and DD) and Gbeta3 TT homozygotes with ID/DD-TT carriers showing a more than five-fold increase in risk for major depression (crude OR = 5.83, 95% CI 1.99-17.08, P = 0.0002). More...
Angiotensin-converting enzyme (ACE) Baghai, 2006 patients and normal controls In the screening sample, two SNPs within the ACE gene were s...... In the screening sample, two SNPs within the ACE gene were significantly associated with unipolar major depression. More...
ACE Angunsri, 2009 patients and normal controls P-value=0.002 on chi(2) test, emP-valueirical P-value=0.004 Haplotype frequency analysis revealed that the -240T/-93T co...... Haplotype frequency analysis revealed that the -240T/-93T combination was significantly over-represented in patients with MDD in comparison with controls (13.6% and 6.8%, p=0.002 on chi(2) test, empirical p=0.004) More...
ACE Firouzabadi N, 2012 patients and normal controls P-value =0.001; odds ratio (OR)=6.2; 95% confidence interval (CI)=2.1-18.3 The results showed, for the first time, that GG genotype of ...... The results showed, for the first time, that GG genotype of ACE A2350G was significantly associated with MDD among Iranian participants (P=0.001; odds ratio (OR)=6.2; 95% confidence interval (CI)=2.1-18.3). More...
ACE Zill P, 2012 patients and normal controls P-value = 0.008 We detected intensive DNA methylation within a recently desc...... We detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) More...

Positive relationships between ACE and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of ACE in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between ACE and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
ACE Segman RH, 2002 Patients and nomal controls There was no evidence for allelic or genotypic association o...... There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia More...

Negative relationships between ACE and other components at different levels (count: 0) Help
ACE related SNPs in MK4MDD (count: 1)
ACE related proteins in MK4MDD (count: 1)
ACE related GO terms (count: 50)
ACE related KEGG pathways (count: 2)
ACE related BioCarta pathways (count: 1)
ACE related Reactome pathways (count: 0)
ACE related interactors from protein-protein interaction data in HPRD (count: 3)