SNP Report

Name	rs4680 dbSNP Ensembl
Location	Chrchr22:19951271(Forward)
Variant Alleles	G/A
Ancestral Allele	G
Annotation	downstream_gene_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant PolyPhen: benign(ENST00000207636' target='_blank'>ENST00000207636, ENST00000361682, ENST00000403184, ENST00000403710, ENST00000406520, ENST00000407537, ENST00000412786, ENST00000428707, ENST00000449653, ENST00000207636' target='_blank'>ENST00000207636) SIFT: tolerated(ENST00000207636' target='_blank'>ENST00000207636, ENST00000361682, ENST00000403184, ENST00000403710, ENST00000406520, ENST00000407537, ENST00000412786, ENST00000428707, ENST00000449653, ENST00000207636' target='_blank'>ENST00000207636)
Consequence to Transcript	downstream_gene_variant(ENST00000467943) missense_variant(ENST00000207636, ENST00000361682, ENST00000403184, ENST00000403710, ENST00000406520, ENST00000407537, ENST00000412786, ENST00000428707, ENST00000449653) nc_transcript_variant(ENST00000493893) NMD_transcript_variant(ENST00000207636) non_coding_exon_variant(ENST00000493893) upstream_gene_variant(ENST00000585066)
No. of Studies (Positive/Negative)	3 (2/1)

Reference	Research Type	Statistical Result	Relation Description
Massat, 2005	patients and normal controls		An association was found between the high-activity COMT Val ...... An association was found between the high-activity COMT Val allele, particularly the COMT Val/Val genotype and early-onset MDD. More...
Bosker, 2010	patients and normal controls		Significance of candidate SNPs for MDD identified from the l...... Significance of candidate SNPs for MDD identified from the literature within the GAIN MDD GWAS More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Reference	Research Type	Statistical Result	Relation Description
lli A, 2010	Patients and nomal controls		We could not demonstrate any significant difference in the d...... We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects More...

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
COMT	catechol-O-methyltransferase	Literature-origin; SNP mapped	6(6/0)
MIR4761	microRNA 4761	SNP mapped	0(0/0)