Gene Report

Basic Information

Approved Symbol	SIGMAR1
Approved Name	sigma non-opioid intracellular receptor 1
Previous Symbol	OPRS1
Previous Name	opioid receptor, sigma 1
Symbol Alias	SR-BP1
Location	9p13.3
Position	chr9:34634719-34637768 (-)
External Links	Entrez Gene: 10280 Ensembl: ENSG00000147955 UCSC: uc003zvb.3 HGNC ID: 8157
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; SNP mapped

Positive relationships between SIGMAR1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
sigma 1 receptor gene (SIGMAR1)	Kishi, 2010	patients and normal controls		In the logistic regression analysis, we detected an associat...... In the logistic regression analysis, we detected an association of the phenotypes (MDD or controls) with rs1800866 in this gene. More...

Positive relationships between SIGMAR1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Oprs1		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice

Positive relationship network of SIGMAR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SIGMAR1 and MDD (count: 0)

Negative relationships between SIGMAR1 and other components at different levels (count: 0)

SIGMAR1 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs1800866	chr9:34637690(Forward)	5_prime_UTR_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(1/0)

SIGMAR1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Sigma non-opioid intracellular receptor 1	Q99720	0(0/0)	Gene mapped

SIGMAR1 related GO terms (count: 17)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0043523	regulation of neuron apoptotic process	biological process	IMP
GO:0005635	nuclear envelope	cellular component	IDA[9341151]
GO:0006696	ergosterol biosynthetic process	biological process	IEA
GO:0005811	lipid particle	cellular component	IEA
GO:0000247	C-8 sterol isomerase activity	molecular function	IEA
GO:0030426	growth cone	cellular component	IEA
GO:0008219	cell death	biological process	IEA
GO:0005640	nuclear outer membrane	cellular component	IEA
GO:0016021	integral to membrane	cellular component	TAS[9453537]
GO:0008144	drug binding	molecular function	TAS[8954936]
GO:0005887	integral to plasma membrane	cellular component	TAS[8954936]
GO:0006869	lipid transport	biological process	IEA
GO:0007399	nervous system development	biological process	IEA
GO:0004985	opioid receptor activity	molecular function	IEA
GO:0005637	nuclear inner membrane	cellular component	IEA

SIGMAR1 related KEGG pathways (count: 0)

SIGMAR1 related BioCarta pathways (count: 0)

SIGMAR1 related Reactome pathways (count: 0)

SIGMAR1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SIGMAR1	ITPR3	No	in vitro;in vivo	11149946
SIGMAR1	ANK2	No	in vitro;in vivo	11149946

Gene Report

Literature-origin GO terms

Gene mapped GO terms