Gene Report

Basic Information

Approved Symbol	PDE11A
Approved Name	phosphodiesterase 11A
Location	2q31.3
Position	chr2:178487977-178973066 (-)
External Links	Entrez Gene: 50940 Ensembl: ENSG00000128655 UCSC: uc002ulq.3 HGNC ID: 8773
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; SNP mapped

Positive relationships between PDE11A and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PDE11A	Wong, 2006	patients and normal controls	P-value<0.0001	In the PDE11A gene, haplotype GAACC in rs1465831-rs3770034-r...... In the PDE11A gene, haplotype GAACC in rs1465831-rs3770034-rs1866212-rs1561320-rs1370656 was found to be significantly associated with a diagnosis of depression (P < 0.0001). More...
PDE11A	Luo, 2009	patients and normal controls		18 common haplotypes (with frequency higher than 0.8%) in th...... 18 common haplotypes (with frequency higher than 0.8%) in this gene have been found in the studied population. Six haplotypes showed significantly different frequencies between the MDD group and the control group. More...

Positive relationships between PDE11A and other components at different levels (count: 0)

Positive relationship network of PDE11A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDE11A and MDD (count: 0)

Negative relationships between PDE11A and other components at different levels (count: 0)

PDE11A related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs3770018	chr2:178540804(Forward)	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(1/0)

PDE11A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Q9HCR9	0(0/0)	Gene mapped

PDE11A related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043204	perikaryon	cellular component	IEA
GO:0006198	cAMP catabolic process	biological process	IEA
GO:0007596	blood coagulation	biological process	TAS
GO:0007165	signal transduction	biological process	IEA
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	molecular function	IEA
GO:0030553	cGMP binding	molecular function	IDA[19689430]
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular function	TAS[10725373]
GO:0005829	cytosol	cellular component	TAS
GO:0005575	cellular_component	cellular component	ND
GO:0046872	metal ion binding	molecular function	IEA
GO:0030552	cAMP binding	molecular function	IEA
GO:0004112	cyclic-nucleotide phosphodiesterase activity	molecular function	NAS[10906126]
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	IDA[19689430]
GO:0046069	cGMP catabolic process	biological process	IEA

PDE11A related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00230	purine metabolism	Purine metabolism

PDE11A related BioCarta pathways (count: 0)

PDE11A related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

PDE11A related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways