Gene Report

Basic Information

Approved Symbol	MC1R
Approved Name	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Symbol Alias	MSH-R
Location	16q24.3
Position	chr16:89986621-89987385 (+)
External Links	Entrez Gene: 4157 Ensembl: ENSG00000258839 HGNC ID: 6929
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between MC1R and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Melanocortin 1 receptor	Wu, 2011	patients and normal controls	P-value=0.05	The frequency of one (H2) of the five haplotypes in this gen...... The frequency of one (H2) of the five haplotypes in this gene identified was higher in depressed patients when compared with controls (P=0.05). More...

Positive relationships between MC1R and other components at different levels (count: 0)

Positive relationship network of MC1R in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MC1R and MDD (count: 0)

Negative relationships between MC1R and other components at different levels (count: 0)

MC1R related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs885479	chr16:89919746(Forward)		1(1/0)

MC1R related proteins in MK4MDD (count: 0)

MC1R related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0010739	positive regulation of protein kinase A signaling	biological process	ISS[18292087]
GO:0004980	melanocyte-stimulating hormone receptor activity	molecular function	IPI[19743876]
GO:0007275	multicellular organism development	biological process	TAS[7581459]
GO:0005515	protein binding	molecular function	IPI[19329486\|19743876]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS[18292087]
GO:0035556	intracellular signal transduction	biological process	ISS[18292087]
GO:0019233	sensory perception of pain	biological process	IEA
GO:0005886	plasma membrane	cellular component	IDA[19452503]; TAS
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[19737927]
GO:0005622	intracellular	cellular component	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[9571181]
GO:0008528	G-protein coupled peptide receptor activity	molecular function	TAS[18292087]
GO:0042438	melanin biosynthetic process	biological process	IEA
GO:0030819	positive regulation of cAMP biosynthetic process	biological process	IDA[19329486\|19743876]
GO:0043473	pigmentation	biological process	TAS[18292087]
GO:0032720	negative regulation of tumor necrosis factor production	biological process	IMP[10233018]
GO:0009650	UV protection	biological process	TAS[7581459]
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[9571181]
GO:0090037	positive regulation of protein kinase C signaling	biological process	ISS[18292087]
GO:0004977	melanocortin receptor activity	molecular function	TAS[9571181]
GO:0070914	UV-damage excision repair	biological process	IDA[18292087]
GO:0051897	positive regulation of protein kinase B signaling	biological process	ISS[18292087]

MC1R related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction
hsa04916	melanogenesis	Melanogenesis	Cutaneous melanin pigment plays a critical role in camouflag...... Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism. More...

MC1R related BioCarta pathways (count: 0)

MC1R related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

MC1R related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MC1R	MC4R	No	in vitro;in vivo	12165561
MC1R	ASIP	No	in vivo	9058374
MC1R	POMC	No	in vivo	10942578 , 11041375

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways