Gene Report

Basic Information

Approved Symbol	PDE8A
Approved Name	phosphodiesterase 8A
Symbol Alias	HsT19550
Location	15q25.3
Position	chr15:85681135-85682373 (+)
External Links	Entrez Gene: 5151 Ensembl: ENSG00000073417 UCSC: uc002blh.3 HGNC ID: 8793
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between PDE8A and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PDE8A	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
PDE8A	Tomita H, 2013	patients and normal controls		GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between PDE8A and other components at different levels (count: 0)

Positive relationship network of PDE8A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDE8A and MDD (count: 0)

Negative relationships between PDE8A and other components at different levels (count: 0)

PDE8A related SNPs in MK4MDD (count: 0)

PDE8A related proteins in MK4MDD (count: 0)

PDE8A related GO terms (count: 9)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular function	NAS[9618252]
GO:0009187	cyclic nucleotide metabolic process	biological process	NAS[9618252]
GO:0007165	signal transduction	biological process	IEA
GO:0070062	extracellular exosome	cellular component	IDA[19056867]
GO:0046872	metal ion binding	molecular function	IEA
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA
GO:0006198	cAMP catabolic process	biological process	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	molecular function	IEA

PDE8A related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00230	purine metabolism	Purine metabolism

PDE8A related BioCarta pathways (count: 0)

PDE8A related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

PDE8A related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways