Gene Report

Basic Information

Approved Symbol	ADCYAP1
Approved Name	adenylate cyclase activating polypeptide 1 (pituitary)
Symbol Alias	PACAP
Name Alias	"prepro-PACAP"
Location	18p11
Position	chr18:909637-912173 (+)
External Links	Entrez Gene: 116 Ensembl: ENSG00000141433 UCSC: uc010dkh.4 HGNC ID: 241
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ADCYAP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Pituitary adenylate cyclase-activating polypeptide	Hashimoto, 2010	patients and normal controls		We found that a genetic variant in the PACAP gene was associ...... We found that a genetic variant in the PACAP gene was associated with MDD. More...

Positive relationships between ADCYAP1 and other components at different levels (count: 0)

Positive relationship network of ADCYAP1 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ADCYAP1 and MDD (count: 0)

Negative relationships between ADCYAP1 and other components at different levels (count: 0)

ADCYAP1 related SNPs in MK4MDD (count: 0)

ADCYAP1 related proteins in MK4MDD (count: 0)

ADCYAP1 related GO terms (count: 54)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005057	receptor signaling protein activity	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0001821	histamine secretion	biological process	IEA
GO:0007267	cell-cell signaling	biological process	TAS[2302217]
GO:0060253	negative regulation of glial cell proliferation	biological process	IEA
GO:0021983	pituitary gland development	biological process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[25451228]
GO:0060078	regulation of postsynaptic membrane potential	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[23800469]
GO:0070445	regulation of oligodendrocyte progenitor proliferation	biological process	IEA
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	biological process	IEA
GO:0019233	sensory perception of pain	biological process	IEA
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA
GO:0005184	neuropeptide hormone activity	molecular function	IDA[23800469]
GO:0005102	receptor binding	molecular function	IPI[7680413]
GO:0001662	behavioral fear response	biological process	IEA
GO:0090274	positive regulation of somatostatin secretion	biological process	IEA
GO:0007218	neuropeptide signaling pathway	biological process	IDA[23800469]
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	biological process	IDA[24696163]
GO:0019933	cAMP-mediated signaling	biological process	IMP[23800469]
GO:0045909	positive regulation of vasodilation	biological process	IEA
GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus	biological process	IEA
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IEA
GO:0016521	pituitary adenylate cyclase activating polypeptide activity	molecular function	IDA[9603988]
GO:0034260	negative regulation of GTPase activity	biological process	IEA
GO:0005829	cytosol	cellular component	IEA
GO:0060124	positive regulation of growth hormone secretion	biological process	IEA
GO:0031175	neuron projection development	biological process	IDA[23800469]
GO:0051428	peptide hormone receptor binding	molecular function	IDA[11175907]; IPI[17470806]
GO:0043547	positive regulation of GTPase activity	biological process	IDA[23800469]
GO:0045786	negative regulation of cell cycle	biological process	IEA
GO:0005615	extracellular space	cellular component	IEA
GO:0001541	ovarian follicle development	biological process	IEA
GO:0007190	activation of adenylate cyclase activity	biological process	TAS
GO:0007565	female pregnancy	biological process	TAS[10698193]
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	biological process	IDA[11175907]
GO:0032880	regulation of protein localization	biological process	IDA[9603988]
GO:0005576	extracellular region	cellular component	TAS
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IDA[9603988]
GO:0008284	positive regulation of cell proliferation	biological process	IEA
GO:0010976	positive regulation of neuron projection development	biological process	IEA
GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	molecular function	IEA
GO:0046034	ATP metabolic process	biological process	IEA
GO:0043267	negative regulation of potassium ion transport	biological process	IEA
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0042594	response to starvation	biological process	IEA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[23800469]
GO:0005622	intracellular	cellular component	IMP[23800469]
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[23800469]
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS
GO:0010656	negative regulation of muscle cell apoptotic process	biological process	IEA
GO:0045471	response to ethanol	biological process	IEA

ADCYAP1 related KEGG pathways (count: 0)

ADCYAP1 related BioCarta pathways (count: 0)

ADCYAP1 related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11061	signalling by_ngf	Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles i...... Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling. More...
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_18372	class b2_secretin_family_receptors	This family is known as Family B. This family is known as Family B.
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_18377	glucagon type_ligand_receptors	The glucagon hormone family regulates the activity of GPCRs ...... The glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B. More...

ADCYAP1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ADCYAP1	SHH	No	in vitro	12417650
ADCYAP1	MME	No	in vitro	9313778
ADCYAP1	ADCYAP1R1	No	in vitro;in vivo	10583729 , 8253796
ADCYAP1	VIPR1	No	in vitro	12429744
ADCYAP1	VIPR2	No	in vitro;in vivo	8146174
ADCYAP1	CASP2	No	in vitro;in vivo;yeast 2-hybrid	11972030 , 11350957
ADCYAP1	SCTR	No	in vitro;in vivo	1335692

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways