
Gene Report
Approved Symbol | MBP |
---|---|
Approved Name | myelin basic protein |
Location | 18q23 |
Position | chr18:74690789-74844774 (-) |
External Links |
Entrez Gene: 4155 Ensembl: ENSG00000197971 UCSC: uc010xfd.2 HGNC ID: 6925 |
No. of Studies (Positive/Negative) | 2(2/0)
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Type | Literature-origin; Protein mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
MBP | Guilloux JP, 2012 | patients and normal controls | genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects | ||
MBP | Sibille E, 2009 | animal model; patients and nomal controls | R=0.88, P-value<5E-6; y slope=1.14 | Downregulated in MDD patients Downregulated in MDD patients |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Myelin basic protein | P02686 | 1(1/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0007268 | synaptic transmission | biological process | TAS[2434243] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0008366 | axon ensheathment | biological process | TAS[2434243] | |
GO:0019911 | structural constituent of myelin sheath | molecular function | IEA | |
GO:0043025 | neuronal cell body | cellular component | IEA | |
GO:0061024 | membrane organization | biological process | IEA | |
GO:0007417 | central nervous system development | biological process | TAS[2434243] | |
GO:0006955 | immune response | biological process | TAS[7504278] | |
GO:0002020 | protease binding | molecular function | IEA | |
GO:0033269 | internode region of axon | cellular component | IEA | |
GO:0009636 | response to toxin | biological process | IEA | |
GO:0005886 | plasma membrane | cellular component | IEA | |
GO:0042552 | myelination | biological process | IEA | |
GO:0043218 | compact myelin | cellular component | IEA | |
GO:0050771 | negative regulation of axonogenesis | biological process | IEA |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
MBP | TRAF6 | No | in vivo | 10346818 | |
MBP | PAK1 | No | in vitro | 14579272 | |
MBP | HLA-DRA | No | in vitro | 9782128 | |
MBP | CTDSP1 | No | in vitro;in vivo | 14743429 | |
MBP | APTX | No | yeast 2-hybrid | 16713569 | |
MBP | IRAK1 | No | in vitro | 10346818 | |
MBP | PRKCI | Yes | in vitro | 10383403 | |
MBP | SRPK1 | No | in vitro | 10390541 | |
MBP | MAG | Yes | in vivo | 12237860 | |
MBP | RAN | No | in vitro;in vivo | 12101123 | |
MBP | MAPK14 | No | in vitro | 15728454 | |
MBP | PRKCA | No | in vitro | 2413024 | |
MBP | MAPKAPK5 | No | in vitro | 9628874 | |
MBP | MELK | No | in vitro | 16216881 | |
MBP | TLK2 | No | in vitro | 10523312 | |
MBP | MAPK11 | No | in vitro | 15728454 | |
MBP | TLK1 | No | in vitro | 10523312 | |
MBP | PRKACA | No | in vitro | 2413024 | |
MBP | DYRK1B | No | in vitro | 10910078 | |
MBP | ATN1 | No | yeast 2-hybrid | 16713569 | |
MBP | PRMT1 | No | in vitro | 4924231 | |
MBP | CDK12 | No | in vitro | 11683387 | |
MBP | PRKCZ | No | in vitro | 10383403 | |
MBP | STK39 | No | in vitro;in vivo | 10980603 | |
MBP | BMP2K | No | in vitro | 11500515 | |
MBP | CLK1 | No | in vitro | 8798720 | |
MBP | ATXN1 | No | yeast 2-hybrid | 16713569 | |
MBP | EFHA1 | No | in vitro | 11124993 | |
MBP | STK4 | No | in vitro | 7665586 | |
MBP | PRKCD | No | in vitro | 11964256 | |
MBP | MAPK1 | Yes | in vitro | 9792705 , 12760422 , 15380617 | |
MBP | MMP7 | No | in vitro | 8786845 | |
MBP | TRPM7 | No | in vitro | 14594813 | |
MBP | PLP1 | Yes | in vitro | 6083474 , 2467009 | |
MBP | MAPK3 | No | in vitro | 10339476 | |
MBP | PRMT5 | No | in vitro | 11152681 | |
MBP | MAPK13 | No | in vitro | 9207191 | |
MBP | MAPK15 | No | in vitro | 11875070 | |
MBP | MKNK1 | No | in vitro | 9155018 | |
MBP | RTN4 | No | in vivo | 12377379 | |
MBP | STK16 | No | in vitro;in vivo | 10947953 | |
MBP | RPS6KA5 | No | in vitro | 9873047 | |
MBP | NEK9 | No | in vitro | 11864968 |