Gene Report

Basic Information

Approved Symbol	CNP
Approved Name	2',3'-cyclic nucleotide 3' phosphodiesterase
Location	17q21
Position	chr17:40125943-40127192 (+)
External Links	Entrez Gene: 1267 Ensembl: ENSG00000173786 UCSC: uc002hyl.1 HGNC ID: 2158
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between CNP and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CNP	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
CNP	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.14	Downregulated in MDD patients Downregulated in MDD patients

Positive relationships between CNP and other components at different levels (count: 0)

Positive relationship network of CNP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CNP and MDD (count: 0)

Negative relationships between CNP and other components at different levels (count: 0)

CNP related SNPs in MK4MDD (count: 0)

CNP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P09543	1(1/0)	Literature-origin

CNP related GO terms (count: 32)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[1322358]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030900	forebrain development	biological process	IEA
GO:0035749	myelin sheath adaxonal region	cellular component	IEA
GO:0000226	microtubule cytoskeleton organization	biological process	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0035748	myelin sheath abaxonal region	cellular component	IEA
GO:0009214	cyclic nucleotide catabolic process	biological process	IEA
GO:0005741	mitochondrial outer membrane	cellular component	IEA
GO:0046902	regulation of mitochondrial membrane permeability	biological process	IEA
GO:0042470	melanosome	cellular component	IEA
GO:0005634	nucleus	cellular component	IDA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0007568	aging	biological process	IEA
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0031143	pseudopodium	cellular component	IEA
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	molecular function	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA[12379507]
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0048709	oligodendrocyte differentiation	biological process	IEA
GO:0009636	response to toxic substance	biological process	IEA
GO:0021762	substantia nigra development	biological process	IEP[22926577]
GO:0030551	cyclic nucleotide binding	molecular function	IEA
GO:0005743	mitochondrial inner membrane	cellular component	IEA
GO:0005615	extracellular space	cellular component	IDA[12379507]
GO:0008344	adult locomotory behavior	biological process	IEA
GO:0003723	RNA binding	molecular function	IEA
GO:0005654	nucleoplasm	cellular component	IDA
GO:0005902	microvillus	cellular component	IEA
GO:0007409	axonogenesis	biological process	IEA
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|19199708\|23376485\|23533145]
GO:0005874	microtubule	cellular component	IDA[21525035]

CNP related KEGG pathways (count: 0)

CNP related BioCarta pathways (count: 0)

CNP related Reactome pathways (count: 0)

CNP related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CNP	MTNR1A	No	in vivo	17215244
CNP	TUBA1A	No	in vitro	11842207
CNP	PRKCD	No	in vitro	10646504

Gene Report

Literature-origin GO terms

Gene mapped GO terms