Gene Report

Basic Information

Approved Symbol	GRM3
Approved Name	glutamate receptor, metabotropic 3
Symbol Alias	GPRC1C, mGlu3, MGLUR3
Location	7q21.1-q21.2
Position	chr7:86493713-86494193 (+)
External Links	Entrez Gene: 2913 Ensembl: ENSG00000198822 UCSC: uc003uid.3 HGNC ID: 4595
No. of Studies (Positive/Negative)	4(3/1)
Type	Literature-origin; Protein mapped

Positive relationships between GRM3 and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GRM3	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...
GRM3	Tsunoka, 2009	patients and normal controls	P-value=0.0371	We found an association between rs6465084 in GRM3 and MDD in...... We found an association between rs6465084 in GRM3 and MDD in the allele-wise analysis after Bonferroni's correction (P-value=0.0371). More...
GRM3	Tomita H, 2013	patients and normal controls		GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between GRM3 and other components at different levels (count: 0)

Positive relationship network of GRM3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GRM3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GRM3	Jia W, 2014	patients and normal controls		We found that GRM3 polymorphisms modulate the susceptibility...... We found that GRM3 polymorphisms modulate the susceptibility to HD but do not significantly influence the risk for schizophrenia or depression. More...

Negative relationships between GRM3 and other components at different levels (count: 0)

GRM3 related SNPs in MK4MDD (count: 0)

GRM3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Metabotropic glutamate receptor 3	Q14832	1(1/0)	Literature-origin

GRM3 related GO terms (count: 14)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0007268	synaptic transmission	biological process	TAS[8840013]
GO:0043197	dendritic spine	cellular component	IEA
GO:0014069	postsynaptic density	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[8840013]
GO:0005886	plasma membrane	cellular component	TAS
GO:0005246	calcium channel regulator activity	molecular function	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[8840013]
GO:0042734	presynaptic membrane	cellular component	IBA
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	biological process	IBA
GO:0001641	group II metabotropic glutamate receptor activity	molecular function	IEA
GO:0007194	negative regulation of adenylate cyclase activity	biological process	TAS[8840013]
GO:0030424	axon	cellular component	IEA
GO:0008066	glutamate receptor activity	molecular function	TAS[8840013]

GRM3 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GRM3 related BioCarta pathways (count: 0)

GRM3 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_18319	class c3_metabotropic_glutamate_pheromone_receptors	The class C G-protein-coupled receptors are a class of G-pro...... The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors. Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region. More...

GRM3 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GRM3	CALM1	Yes	yeast 2-hybrid	15494036
GRM3	PICK1	No	in vivo	11891216
GRM3	GRASP	No	yeast 2-hybrid	11850456
GRM3	PPM1A	Yes	in vitro	14663150
GRM3	SDCBP	No	in vitro;in vivo;yeast 2-hybrid	11891216

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways