MK4MDD

Gene Report

Basic Information
Approved Symbol GRM3
Approved Name glutamate receptor, metabotropic 3
Symbol Alias GPRC1C, mGlu3, MGLUR3
Location 7q21.1-q21.2
Position chr7:86493713-86494193 (+)
External Links Entrez Gene: 2913
Ensembl: ENSG00000198822
UCSC: uc003uid.3
HGNC ID: 4595
No. of Studies (Positive/Negative) 4(3/1) Help
Type Literature-origin; Protein mapped

Positive relationships between GRM3 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GRM3 Klempan, 2009 patients and normal controls Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...
GRM3 Tsunoka, 2009 patients and normal controls P-value=0.0371 We found an association between rs6465084 in GRM3 and MDD in...... We found an association between rs6465084 in GRM3 and MDD in the allele-wise analysis after Bonferroni's correction (P-value=0.0371). More...
GRM3 Tomita H, 2013 patients and normal controls GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between GRM3 and other components at different levels (count: 0) Help
Positive relationship network of GRM3 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GRM3 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
GRM3 Jia W, 2014 patients and normal controls We found that GRM3 polymorphisms modulate the susceptibility...... We found that GRM3 polymorphisms modulate the susceptibility to HD but do not significantly influence the risk for schizophrenia or depression. More...

Negative relationships between GRM3 and other components at different levels (count: 0) Help
GRM3 related SNPs in MK4MDD (count: 0)
GRM3 related proteins in MK4MDD (count: 1)
GRM3 related GO terms (count: 14)
GRM3 related KEGG pathways (count: 1)
GRM3 related BioCarta pathways (count: 0)
GRM3 related Reactome pathways (count: 2)
GRM3 related interactors from protein-protein interaction data in HPRD (count: 5)