Gene Report

Basic Information

Approved Symbol	SLC6A1
Approved Name	solute carrier family 6 (neurotransmitter transporter), member 1
Previous Name	"solute carrier family 6 (neurotransmitter transporter, GABA), member 1"
Symbol Alias	GAT1, GABATR, GABATHG
Name Alias	"GABA transporter 1"
Location	3p25.3
Position	chr3:11078653-11080935 (+)
External Links	Entrez Gene: 6529 Ensembl: ENSG00000157103 UCSC: uc010hdq.3 HGNC ID: 11042
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SLC6A1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC6A1	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between SLC6A1 and other components at different levels (count: 0)

Positive relationship network of SLC6A1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC6A1 and MDD (count: 0)

Negative relationships between SLC6A1 and other components at different levels (count: 0)

SLC6A1 related SNPs in MK4MDD (count: 0)

SLC6A1 related proteins in MK4MDD (count: 0)

SLC6A1 related GO terms (count: 29)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0032355	response to estradiol	biological process	IEA
GO:0014074	response to purine-containing compound	biological process	IEA
GO:0005328	neurotransmitter:sodium symporter activity	molecular function	IEA
GO:0016020	membrane	cellular component	TAS[2387399]
GO:0042220	response to cocaine	biological process	IEA
GO:0005332	gamma-aminobutyric acid:sodium symporter activity	molecular function	IBA
GO:0051260	protein homooligomerization	biological process	IEA
GO:0098779	mitophagy in response to mitochondrial depolarization	biological process	IGI[22020285]
GO:0007269	neurotransmitter secretion	biological process	TAS
GO:0009986	cell surface	cellular component	IEA
GO:0016021	integral component of membrane	cellular component	TAS[8530094]
GO:0005887	integral component of plasma membrane	cellular component	IBA
GO:0043005	neuron projection	cellular component	IBA
GO:0015812	gamma-aminobutyric acid transport	biological process	IBA
GO:0046872	metal ion binding	molecular function	IEA
GO:0009744	response to sucrose	biological process	IEA
GO:0055085	transmembrane transport	biological process	TAS
GO:0006836	neurotransmitter transport	biological process	IBA
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	biological process	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0006810	transport	biological process	NAS[8530094]
GO:0030424	axon	cellular component	IEA
GO:0009636	response to toxic substance	biological process	IEA
GO:0007612	learning	biological process	IEA
GO:0051939	gamma-aminobutyric acid import	biological process	IEA
GO:0051592	response to calcium ion	biological process	IEA
GO:0010288	response to lead ion	biological process	IEA
GO:0032229	negative regulation of synaptic transmission, GABAergic	biological process	IEA

SLC6A1 related KEGG pathways (count: 0)

SLC6A1 related BioCarta pathways (count: 0)

SLC6A1 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_20679	amine compound_slc_transporters	Five SLC gene families encode proteins that mediate transpor...... Five SLC gene families encode proteins that mediate transport of amines. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_20506	na cl_dependent_neurotransmitter_transporters	The SLC6 gene family encodes proteins that mediate neurotran...... The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA. More...
REACT_19305	glucose and_other_sugar_slc_transporters	Hexoses like glucose, galactose and fructose serve as basic ...... Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins. SLC2 family contains 14 genes and encode facilitative glucose transporters. SLC5 family contains 12 genes and encode Na+/glucose symporters. SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers. SLC45 family has 4 members and encode putative sugar/H+ symporters. More...

SLC6A1 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways