Gene Report
Basic Information
| Approved Symbol | DLG2 |
|---|---|
| Approved Name | discs, large homolog 2 (Drosophila) |
| Previous Name | discs, large homolog 2, chapsyn-110 (Drosophila) |
| Symbol Alias | PSD-93, PSD93, chapsyn-110, PPP1R58 |
| Name Alias | protein phosphatase 1, regulatory subunit 58 |
| Location | 11q21 |
| Position | chr11:83166055-85338314 (-) |
| External Links |
Entrez Gene: 1740 Ensembl: ENSG00000150672 UCSC: uc001pak.2 HGNC ID: 2901 |
| No. of Studies (Positive/Negative) | 1(1/0)
|
| Type | Literature-origin |
Positive relationships between DLG2 and MDD (count: 1)
| Name in Literature | Reference | Research Type | Statistical Result | Relation Description | |
|---|---|---|---|---|---|
| DLG2 | Duric V, 2012 | patients and normal controls | Our findings demonstrate significant dysregulation of synapt...... Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3 More... |
Positive relationships between DLG2 and other components at different levels (count: 0)
Positive relationship network of DLG2 in MK4MDD
Network loading ...
Note:
1. The different color of the nodes denotes the level of the nodes.
| Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between DLG2 and MDD (count: 0)
Negative relationships between DLG2 and other components at different levels (count: 0)
DLG2 related SNPs in MK4MDD (count: 0)
DLG2 related proteins in MK4MDD (count: 1)
| Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
|---|---|---|---|---|
| Disks large homolog 2 | Q15700 | 0(0/0) | Gene mapped |
DLG2 related GO terms (count: 10)
Literature-origin GO terms | ||||
| ID | Name | Type | Evidence | |
|---|---|---|---|---|
| GO:0045211 | postsynaptic membrane | cellular component | IEA | |
| GO:0007268 | synaptic transmission | biological process | IEA | |
| GO:0030054 | cell junction | cellular component | IEA | |
Gene mapped GO terms | ||||
| ID | Name | Type | Evidence | |
|---|---|---|---|---|
| GO:0005515 | protein binding | molecular function | IPI[15304517] | |
| GO:0010923 | negative regulation of phosphatase activity | biological process | IDA[19389623] | |
| GO:0044224 | juxtaparanode region of axon | cellular component | IEA | |
| GO:0005886 | plasma membrane | cellular component | IEA | |
| GO:0004385 | guanylate kinase activity | molecular function | TAS[8755482] | |
| GO:0019233 | sensory perception of pain | biological process | IEA | |
| GO:0014069 | postsynaptic density | cellular component | IEA | |
DLG2 related KEGG pathways (count: 0)
DLG2 related BioCarta pathways (count: 0)
DLG2 related Reactome pathways (count: 0)
DLG2 related interactors from protein-protein interaction data in HPRD (count: 37)
| Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
|---|---|---|---|---|---|
| DLG2 | GRID2 | Yes | in vivo;yeast 2-hybrid | 10234023 | |
| DLG2 | NLGN3 | No | yeast 2-hybrid | 9278515 | |
| DLG2 | KCNJ2 | No | in vitro;yeast 2-hybrid | 15304517 | |
| DLG2 | KCNA4 | Yes | in vitro | 11997254 | |
| DLG2 | DLGAP1 | Yes | yeast 2-hybrid | 11122378 | |
| DLG2 | KIF1B | No | in vitro | 16637659 | |
| DLG2 | MAP1A | Yes | in vivo | 9786987 | |
| DLG2 | ATP2B2 | No | in vitro;in vivo | 11274188 | |
| DLG2 | LRP2 | No | in vitro;yeast 2-hybrid | 12713445 | |
| DLG2 | GRID1 | No | yeast 2-hybrid | 10234023 | |
| DLG2 | ABCA1 | No | in vitro | 16192276 | |
| DLG2 | SEMA4C | No | in vitro;in vivo;yeast 2-hybrid | 11134026 | |
| DLG2 | FZD1 | No | yeast 2-hybrid | 12067714 | |
| DLG2 | WNT3A | No | yeast 2-hybrid | 12067714 | |
| DLG2 | GRIN2A | Yes | in vitro;in vivo | 10648730 , 12890763 | |
| DLG2 | FZD7 | No | yeast 2-hybrid | 12067714 | |
| DLG2 | GRIN2B | Yes | in vitro;in vivo | 9806853 , 11997254 , 12890763 | |
| DLG2 | KCNJ12 | No | in vitro;in vivo | 15024025 | |
| DLG2 | NOS1 | No | in vitro;yeast 2-hybrid | 8625413 , 8922396 | |
| DLG2 | GRIN2D | No | in vivo | 10862698 | |
| DLG2 | DLG4 | Yes | in vivo | 9182804 | |
| DLG2 | GUCY1A2 | No | in vitro | 11572861 | |
| DLG2 | KCNJ4 | No | in vitro | 11997254 | |
| DLG2 | CNKSR2 | No | in vitro | 16637659 | |
| DLG2 | MAPK12 | Yes | in vitro | 16637659 | |
| DLG2 | LIN7A | No | in vitro | 9753324 | |
| DLG2 | FZD4 | No | yeast 2-hybrid | 12067714 | |
| DLG2 | CRIPT | No | in vitro;in vivo;yeast 2-hybrid | 9581762 , 12070168 | |
| DLG2 | DLG1 | No | in vivo | 12351654 | |
| DLG2 | CACNG2 | No | in vitro | 16637659 | |
| DLG2 | ERBB4 | No | in vitro;in vivo;yeast 2-hybrid | 10725395 | |
| DLG2 | SCN4A | No | in vitro | 16637659 | |
| DLG2 | ATP2B4 | No | in vitro;in vivo | 11274188 | |
| DLG2 | GLS2 | No | in vitro | 16637659 | |
| DLG2 | SCN5A | No | in vitro | 16637659 | |
| DLG2 | DLG2 | Yes | in vivo | 9677374 | |
| DLG2 | GRIN1 | No | in vivo | 10862698 |