Gene Report

Basic Information

Approved Symbol	DLG2
Approved Name	discs, large homolog 2 (Drosophila)
Previous Name	"discs, large homolog 2, chapsyn-110 (Drosophila)"
Symbol Alias	PSD-93, PSD93, chapsyn-110, PPP1R58
Name Alias	"protein phosphatase 1, regulatory subunit 58"
Location	11q21
Position	chr11:85338262-85338314 (-)
External Links	Entrez Gene: 1740 Ensembl: ENSG00000150672 UCSC: uc001pak.2 HGNC ID: 2901
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DLG2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DLG2	Duric V, 2012	patients and normal controls		Our findings demonstrate significant dysregulation of synapt...... Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3 More...

Positive relationships between DLG2 and other components at different levels (count: 0)

Positive relationship network of DLG2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DLG2 and MDD (count: 0)

Negative relationships between DLG2 and other components at different levels (count: 0)

DLG2 related SNPs in MK4MDD (count: 0)

DLG2 related proteins in MK4MDD (count: 0)

DLG2 related GO terms (count: 23)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0014069	postsynaptic density	cellular component	IBA
GO:0007268	synaptic transmission	biological process	IBA
GO:0045211	postsynaptic membrane	cellular component	IBA
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016020	membrane	cellular component	ISS
GO:0007399	nervous system development	biological process	IBA
GO:0046037	GMP metabolic process	biological process	TAS[8755482]
GO:0097481	neuronal postsynaptic density	cellular component	IEA
GO:0016323	basolateral plasma membrane	cellular component	IBA
GO:0005515	protein binding	molecular function	IPI[15304517\|19118189]
GO:0008076	voltage-gated potassium channel complex	cellular component	ISS
GO:0005886	plasma membrane	cellular component	TAS[8755482]
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	biological process	IBA
GO:0043113	receptor clustering	biological process	IBA
GO:0035255	ionotropic glutamate receptor binding	molecular function	IBA
GO:0008328	ionotropic glutamate receptor complex	cellular component	IBA
GO:0097120	receptor localization to synapse	biological process	IBA
GO:0019900	kinase binding	molecular function	IDA[21119615]
GO:0004385	guanylate kinase activity	molecular function	TAS[8755482]
GO:0044224	juxtaparanode region of axon	cellular component	ISS
GO:0010923	negative regulation of phosphatase activity	biological process	IDA[19389623]
GO:0046710	GDP metabolic process	biological process	TAS[8755482]
GO:0019233	sensory perception of pain	biological process	IEA

DLG2 related KEGG pathways (count: 0)

DLG2 related BioCarta pathways (count: 0)

DLG2 related Reactome pathways (count: 0)

DLG2 related interactors from protein-protein interaction data in HPRD (count: 37)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DLG2	ABCA1	No	in vitro	16192276
DLG2	KCNJ4	No	in vitro	11997254
DLG2	DLG4	Yes	in vivo	9182804
DLG2	FZD7	No	yeast 2-hybrid	12067714
DLG2	MAPK12	Yes	in vitro	16637659
DLG2	DLGAP1	Yes	yeast 2-hybrid	11122378
DLG2	MAP1A	Yes	in vivo	9786987
DLG2	CRIPT	No	in vitro;in vivo;yeast 2-hybrid	9581762 , 12070168
DLG2	NLGN3	No	yeast 2-hybrid	9278515
DLG2	ATP2B2	No	in vitro;in vivo	11274188
DLG2	CNKSR2	No	in vitro	16637659
DLG2	LRP2	No	in vitro;yeast 2-hybrid	12713445
DLG2	ERBB4	No	in vitro;in vivo;yeast 2-hybrid	10725395
DLG2	GRIN2A	Yes	in vitro;in vivo	10648730 , 12890763
DLG2	KCNJ2	Yes	in vitro;yeast 2-hybrid	15304517
DLG2	DLG1	No	in vivo	12351654
DLG2	FZD4	No	yeast 2-hybrid	12067714
DLG2	GRIN1	No	in vivo	10862698
DLG2	SCN5A	No	in vitro	16637659
DLG2	GRIN2D	No	in vivo	10862698
DLG2	KCNJ12	No	in vitro;in vivo	15024025
DLG2	NOS1	Yes	in vitro;yeast 2-hybrid	8625413 , 8922396
DLG2	SCN4A	No	in vitro	16637659
DLG2	LIN7A	No	in vitro	9753324
DLG2	ATP2B4	No	in vitro;in vivo	11274188
DLG2	KCNA4	Yes	in vitro	11997254
DLG2	GRID2	Yes	in vivo;yeast 2-hybrid	10234023
DLG2	GRIN2B	Yes	in vitro;in vivo	9806853 , 11997254 , 12890763
DLG2	CACNG2	No	in vitro	16637659
DLG2	GLS2	No	in vitro	16637659
DLG2	KIF1B	No	in vitro	16637659
DLG2	SEMA4C	No	in vitro;in vivo;yeast 2-hybrid	11134026
DLG2	GRID1	No	yeast 2-hybrid	10234023
DLG2	WNT3A	No	yeast 2-hybrid	12067714
DLG2	GUCY1A2	No	in vitro	11572861
DLG2	DLG2	Yes	in vivo	9677374
DLG2	FZD1	No	yeast 2-hybrid	12067714

Gene Report

Literature-origin GO terms

Gene mapped GO terms