Gene Report

Basic Information

Approved Symbol	MAP1A
Approved Name	microtubule-associated protein 1A
Previous Symbol	MAP1L
Location	15q15.3
Position	chr15:43822423-43823814 (+)
External Links	Entrez Gene: 4130 Ensembl: ENSG00000166963 UCSC: uc001zrt.3 HGNC ID: 6835
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between MAP1A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MAP1A	Duric V, 2012	patients and normal controls		Our findings demonstrate significant dysregulation of synapt...... Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3 More...

Positive relationships between MAP1A and other components at different levels (count: 0)

Positive relationship network of MAP1A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MAP1A and MDD (count: 0)

Negative relationships between MAP1A and other components at different levels (count: 0)

MAP1A related SNPs in MK4MDD (count: 0)

MAP1A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Microtubule-associated protein 1A	P78559	1(1/0)	Literature-origin

MAP1A related GO terms (count: 17)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0002230	positive regulation of defense response to virus by host	biological process	IMP[22020285]
GO:0005829	cytosol	cellular component	IEA
GO:0098792	xenophagy	biological process	IMP[22020285]
GO:0005198	structural molecule activity	molecular function	NAS[8812494]
GO:0045494	photoreceptor cell maintenance	biological process	IEA
GO:0005518	collagen binding	molecular function	IEA
GO:0003779	actin binding	molecular function	IEA
GO:0098779	mitophagy in response to mitochondrial depolarization	biological process	IGI[22020285]
GO:0005515	protein binding	molecular function	IPI[12812986\|15525354]
GO:0005874	microtubule	cellular component	IEA
GO:0097481	neuronal postsynaptic density	cellular component	IEA
GO:0008017	microtubule binding	molecular function	IEA
GO:0007026	negative regulation of microtubule depolymerization	biological process	IEA
GO:0007605	sensory perception of sound	biological process	IEA
GO:0001750	photoreceptor outer segment	cellular component	IEA
GO:0000226	microtubule cytoskeleton organization	biological process	IEA
GO:0005875	microtubule associated complex	cellular component	IEA

MAP1A related KEGG pathways (count: 0)

MAP1A related BioCarta pathways (count: 0)

MAP1A related Reactome pathways (count: 0)

MAP1A related interactors from protein-protein interaction data in HPRD (count: 20)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MAP1A	TUBA4A	No	in vitro;in vivo	9593747 , 11278895
MAP1A	TUBB	No	in vitro	11278895
MAP1A	MAP1B	No	in vitro;in vivo	11002287 , 2470876
MAP1A	DLG4	Yes	in vitro;in vivo;yeast 2-hybrid	9786987 , 11925566
MAP1A	UPF2	No	yeast 2-hybrid	15231747
MAP1A	CACNB4	No	yeast 2-hybrid	16525042
MAP1A	MAP1LC3A	No	in vitro;in vivo	2470876 , 7908909
MAP1A	DLG2	Yes	in vivo	9786987
MAP1A	KCNMA1	No	in vivo;yeast 2-hybrid	15251455
MAP1A	DISC1	Yes	in vivo;yeast 2-hybrid	12812986
MAP1A	HTR2A	Yes	yeast 2-hybrid	16537434
MAP1A	AP1G1	No	in vitro;in vivo	11418592 , 10747088
MAP1A	ARHGEF11	No	in vitro;in vivo;yeast 2-hybrid	16478718
MAP1A	RAPGEF3	No	in vitro;in vivo;yeast 2-hybrid	15202935
MAP1A	DLG1	No	in vivo	9786987
MAP1A	ACTG1	No	in vitro	7820861
MAP1A	NXF2	No	yeast 2-hybrid	16014633
MAP1A	RAPGEF4	No	in vivo	15202935
MAP1A	ACTA1	No	in vitro	7820861 , 7908020
MAP1A	NXF1	No	yeast 2-hybrid	16014633

Gene Report

Gene mapped GO terms