Gene Report

Basic Information

Approved Symbol	HTR3B
Approved Name	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
Previous Name	"5-hydroxytryptamine (serotonin) receptor 3B"
Symbol Alias	5-HT3B
Location	11q23.1
Position	chr11:113816860-113817283 (+)
External Links	Entrez Gene: 9177 Ensembl: ENSG00000149305 UCSC: uc001pok.3 HGNC ID: 5298
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between HTR3B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HTR3B	Yamada, 2006	patients and normal controls	P-value=0.0023	In HTR3B, haplotype block 2 that included a nonsynonymous si...... In HTR3B, haplotype block 2 that included a nonsynonymous single nucleotide polymorphism (SNP), yielded evidence of association with major depression in females (global p = .0023). More...

Positive relationships between HTR3B and other components at different levels (count: 0)

Positive relationship network of HTR3B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HTR3B and MDD (count: 0)

Negative relationships between HTR3B and other components at different levels (count: 0)

HTR3B related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs1176744	chr11:113932306(Forward)		1(1/0)

HTR3B related proteins in MK4MDD (count: 0)

HTR3B related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[9950429]
GO:0045211	postsynaptic membrane	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005887	integral component of plasma membrane	cellular component	TAS[9950429]
GO:0004993	G-protein coupled serotonin receptor activity	molecular function	TAS[9950429]
GO:0042166	acetylcholine binding	molecular function	IBA
GO:0006810	transport	biological process	TAS[9950429]
GO:0009986	cell surface	cellular component	IDA[16571125]
GO:0007210	serotonin receptor signaling pathway	biological process	TAS[9950429]
GO:0034220	ion transmembrane transport	biological process	TAS
GO:0055085	transmembrane transport	biological process	TAS
GO:0098655	cation transmembrane transport	biological process	TAS[9950429]
GO:0005886	plasma membrane	cellular component	TAS
GO:0007271	synaptic transmission, cholinergic	biological process	IBA
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	IBA
GO:0005232	serotonin-activated cation-selective channel activity	molecular function	TAS[9950429]
GO:0005216	ion channel activity	molecular function	TAS[9950429]
GO:0015464	acetylcholine receptor activity	molecular function	IBA
GO:0005892	acetylcholine-gated channel complex	cellular component	IBA

HTR3B related KEGG pathways (count: 0)

HTR3B related BioCarta pathways (count: 0)

HTR3B related Reactome pathways (count: 0)

HTR3B related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms