Gene Report

Basic Information

Approved Symbol	GABRD
Approved Name	gamma-aminobutyric acid (GABA) A receptor, delta
Name Alias	"GABA(A) receptor, delta"
Location	1p36.3
Position	chr1:1961722-1962192 (+)
External Links	Entrez Gene: 2563 Ensembl: ENSG00000187730 UCSC: uc001aip.2 HGNC ID: 4084
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GABRD and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GABRD	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between GABRD and other components at different levels (count: 0)

Positive relationship network of GABRD in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GABRD and MDD (count: 0)

Negative relationships between GABRD and other components at different levels (count: 0)

GABRD related SNPs in MK4MDD (count: 0)

GABRD related proteins in MK4MDD (count: 0)

GABRD related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0007268	synaptic transmission	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005887	integral component of plasma membrane	cellular component	TAS[2176788]
GO:0004890	GABA-A receptor activity	molecular function	IEA
GO:0007165	signal transduction	biological process	TAS[2176788]
GO:0005230	extracellular ligand-gated ion channel activity	molecular function	IEA
GO:0005254	chloride channel activity	molecular function	IEA
GO:0034707	chloride channel complex	cellular component	IEA
GO:1902476	chloride transmembrane transport	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16189514\|25416956]
GO:0006810	transport	biological process	TAS[2176788]
GO:1902711	GABA-A receptor complex	cellular component	IBA

GABRD related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GABRD related BioCarta pathways (count: 0)

GABRD related Reactome pathways (count: 0)

GABRD related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GABRD	UBQLN1	No	yeast 2-hybrid	16189514
GABRD	UBQLN4	No	yeast 2-hybrid	16713569

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways