Gene Report

Basic Information

Approved Symbol	KCNN3
Approved Name	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Symbol Alias	KCa2.3, hSK3, SKCA3
Location	1q21.3
Position	chr1:154842441-154842754 (-)
External Links	Entrez Gene: 3782 Ensembl: ENSG00000143603 UCSC: uc021pah.1 HGNC ID: 6292
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between KCNN3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KCNN3	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between KCNN3 and other components at different levels (count: 0)

Positive relationship network of KCNN3 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KCNN3 and MDD (count: 0)

Negative relationships between KCNN3 and other components at different levels (count: 0)

KCNN3 related SNPs in MK4MDD (count: 0)

KCNN3 related proteins in MK4MDD (count: 0)

KCNN3 related GO terms (count: 8)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0071805	potassium ion transmembrane transport	biological process	IBA; IEA
GO:0005516	calmodulin binding	molecular function	IBA
GO:1903955	positive regulation of protein targeting to mitochondrion	biological process	IMP[24270810]
GO:0016021	integral component of membrane	cellular component	IEA
GO:0016286	small conductance calcium-activated potassium channel activity	molecular function	IBA
GO:0005886	plasma membrane	cellular component	IBA; TAS
GO:0043025	neuronal cell body	cellular component	IBA

KCNN3 related KEGG pathways (count: 0)

KCNN3 related BioCarta pathways (count: 0)

KCNN3 related Reactome pathways (count: 0)

KCNN3 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms