Gene Report

Basic Information

Approved Symbol	USP14
Approved Name	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Previous Name	"ubiquitin specific protease 14 (tRNA-guanine transglycosylase)"
Symbol Alias	TGT
Location	18p11.32
Position	chr18:211285-212227 (+)
External Links	Entrez Gene: 9097 Ensembl: ENSG00000101557 UCSC: uc002kkf.1 HGNC ID: 12612
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between USP14 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
USP14	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.003, F=8.2; Substance: P-value=0.008, F=8.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between USP14 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
USP14		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.003, F=8.2; Substance: P-value=0.008, F=8.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of USP14 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between USP14 and MDD (count: 0)

Negative relationships between USP14 and other components at different levels (count: 0)

USP14 related SNPs in MK4MDD (count: 0)

USP14 related proteins in MK4MDD (count: 0)

USP14 related GO terms (count: 20)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004843	thiol-dependent ubiquitin-specific protease activity	molecular function	IDA[23958854]
GO:0010951	negative regulation of endopeptidase activity	biological process	IMP[18162577]
GO:0070628	proteasome binding	molecular function	IDA[18162577]
GO:0008193	tRNA guanylyltransferase activity	molecular function	TAS[8579355]
GO:0016579	protein deubiquitination	biological process	IDA[23958854]
GO:0000502	proteasome complex	cellular component	IEA
GO:0070062	extracellular exosome	cellular component	IDA[23533145]
GO:0005737	cytoplasm	cellular component	IDA
GO:0004197	cysteine-type endopeptidase activity	molecular function	TAS[9827704]
GO:0045202	synapse	cellular component	IEA
GO:0050920	regulation of chemotaxis	biological process	IMP[19106094]
GO:0005886	plasma membrane	cellular component	IEA
GO:0004866	endopeptidase inhibitor activity	molecular function	IMP[18162577]
GO:0016023	cytoplasmic, membrane-bounded vesicle	cellular component	IDA[19106094]
GO:0005515	protein binding	molecular function	IPI[19106094\|19135427\|19896943]
GO:0009986	cell surface	cellular component	IDA[19106094]
GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	biological process	IMP[19135427]
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	IEA
GO:0061136	regulation of proteasomal protein catabolic process	biological process	IMP[18162577]

USP14 related KEGG pathways (count: 0)

USP14 related BioCarta pathways (count: 0)

USP14 related Reactome pathways (count: 0)

USP14 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms