Gene Report

Basic Information

Approved Symbol	RHCG
Approved Name	Rh family, C glycoprotein
Previous Symbol	C15orf6
Previous Name	"chromosome 15 open reading frame 6", "Rhesus blood group, C glycoprotein"
Symbol Alias	RHGK, PDRC2, SLC42A3
Location	15q25
Position	chr15:90039776-90039799 (-)
External Links	Entrez Gene: 51458 Ensembl: ENSG00000140519 UCSC: uc002bnz.2 HGNC ID: 18140
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RHCG and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RHCG	Verma, 2008	patients and normal controls		LD mapping showed nominally significant association in NTRK3...... LD mapping showed nominally significant association in NTRK3, FLJ12484, RHCG, DKFZp547K1113, VPS33B, SV2B, SLCO3A1, RGMA, and MCTP2 with MDD-RE More...

Positive relationships between RHCG and other components at different levels (count: 0)

Positive relationship network of RHCG in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RHCG and MDD (count: 0)

Negative relationships between RHCG and other components at different levels (count: 0)

RHCG related SNPs in MK4MDD (count: 0)

RHCG related proteins in MK4MDD (count: 0)

RHCG related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0070634	transepithelial ammonium transport	biological process	IDA[18032481]
GO:0016323	basolateral plasma membrane	cellular component	IDA[16928804]
GO:0030506	ankyrin binding	molecular function	IDA[12719424]
GO:0006873	cellular ion homeostasis	biological process	IDA[14761968]
GO:0006885	regulation of pH	biological process	IEA
GO:0030855	epithelial cell differentiation	biological process	NAS[12204676]
GO:0015837	amine transport	biological process	NAS[10852913]
GO:0015696	ammonium transport	biological process	IDA[14761968\|15929723\|16580862\|18032481]; IGI[11062476]
GO:0019740	nitrogen utilization	biological process	IBA
GO:0016324	apical plasma membrane	cellular component	IDA[16928804\|18032481]
GO:0008519	ammonium transmembrane transporter activity	molecular function	IDA[14761968\|15929723\|16580862\|18032481]; IGI[11062476]
GO:0042592	homeostatic process	biological process	NAS[10852913]
GO:0072488	ammonium transmembrane transport	biological process	IEA
GO:0005887	integral component of plasma membrane	cellular component	IDA[10852913]
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|23533145]
GO:0015695	organic cation transport	biological process	IBA
GO:0006995	cellular response to nitrogen starvation	biological process	IBA
GO:0005886	plasma membrane	cellular component	IDA[12204676\|15929723]; TAS
GO:0055085	transmembrane transport	biological process	TAS
GO:0031410	cytoplasmic vesicle	cellular component	ISS

RHCG related KEGG pathways (count: 0)

RHCG related BioCarta pathways (count: 0)

RHCG related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19305	glucose and_other_sugar_slc_transporters	Hexoses like glucose, galactose and fructose serve as basic ...... Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins. SLC2 family contains 14 genes and encode facilitative glucose transporters. SLC5 family contains 12 genes and encode Na+/glucose symporters. SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers. SLC45 family has 4 members and encode putative sugar/H+ symporters. More...
REACT_20679	amine compound_slc_transporters	Five SLC gene families encode proteins that mediate transpor...... Five SLC gene families encode proteins that mediate transport of amines. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...

RHCG related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways