Gene Report

Basic Information

Approved Symbol	COPA
Approved Name	coatomer protein complex, subunit alpha
Symbol Alias	HEP-COP
Location	1q23.2
Position	chr1:160258377-160313354 (-)
External Links	Entrez Gene: 1314 Ensembl: ENSG00000122218 UCSC: uc001fvv.4 HGNC ID: 2230
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between COPA and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
COPA	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between COPA and other components at different levels (count: 0)

Positive relationship network of COPA in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between COPA and MDD (count: 0)

Negative relationships between COPA and other components at different levels (count: 0)

COPA related SNPs in MK4MDD (count: 0)

COPA related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Coatomer subunit alpha	P53621	0(0/0)	Gene mapped

COPA related GO terms (count: 11)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005829	cytosol	cellular component	TAS
GO:0048205	COPI coating of Golgi vesicle	biological process	TAS
GO:0030157	pancreatic juice secretion	biological process	IDA[1429581]
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	biological process	TAS
GO:0016044	cellular membrane organization	biological process	TAS
GO:0005615	extracellular space	cellular component	IDA[1429581]
GO:0005737	cytoplasm	cellular component	IDA[9115636]
GO:0005198	structural molecule activity	molecular function	IEA
GO:0030126	COPI vesicle coat	cellular component	IDA[14729954]; ISS
GO:0005179	hormone activity	molecular function	IEA
GO:0006886	intracellular protein transport	biological process	IEA

COPA related KEGG pathways (count: 0)

COPA related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
ARAP_PATHWAY	arap pathway	ADP-Ribosylation Factor	ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotid...... ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins, members of the Ras GTPase superfamily that were initially recognized and purified because of their ability to stimulate the ADP-ribosyltransferase activity of the cholera toxin A subunit. We now know that they are critical components of several different vesicular trafficking pathways in all eukaryotic cells and activators of specific phospholipase Ds (PLDs) (reviewed in Refs. 13). ARF interacts with many proteins and other molecules that regulate its state of activation or are involved in its intracellular function. Arf proteins cycle between GDP-bound, inactive and GTP-bound, active forms, and the cycling is regulated by specific GEPs and GAPs. Members of the Arf GEP family can be grouped into two major subfamilies on the basis of their sequence similarities and functional differences. The high-molecular-weight Arf GEP subfamily includes yeast Sec7, Gea1, and Gea2, and mammalian BIG1/p200, BIG2, and GBF1, which all consist of 1,400 2,000 amino acid residues. Many Arf GAPs are multidomain proteins and have been found to interact with multiple signaling molecules. For instance, ASAP1 has a PH domain, ankyrin (ANK) repeats, proline-rich and Src-homology (SH) 3 domains and has been shown to bind PI(4,5)P2, Src, and Crk. PAPa/PAG3, with a similar domain structure, binds phosphoinositides, Src, Pyk, and paxillin. The GITs bind bARK, paxillin and the Rac/Cdc42 exchange factor PIX (also known as Cool). ASAP-related proteins, ARAP1, 2 and 3 have Arf GAP, Rho GAP,Ankyrin repeat, Ras-associating (RA), and five PH domains, and therefore have the potential of integrating four signaling pathways. More...

COPA related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...
REACT_11096	copi mediated_transport	Secretory transport depends on membrane-bounded carriers to ...... Secretory transport depends on membrane-bounded carriers to move protein and lipid between intracellular compartments. The COPI coat has a central role in this process, creating a sorting domain on the membrane into which cargo proteins, destined to return to the endoplasmic reticulum (ER), concentrate. The membrane domain deforms into a coated bud, pinches off the membrane as a coated carrier, and then uncoats. Successful operation of the COPI coat system is necessary for selective retrieval of protein and lipid components back to the ER. More...

COPA related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
COPA	COPB2	No	in vivo	8940050 , 8537409
COPA	SACM1L	No	in vivo	14527956
COPA	STX8	No	in vivo	12388752
COPA	MTNR1B	No	in vivo	17215244
COPA	SLC25A11	No	yeast 2-hybrid	16169070
COPA	TMED2	No	in vitro	8703076
COPA	ARCN1	No	in vivo	8940050
COPA	PDGFRB	No	in vitro;in vivo	9207175
COPA	COPE	No	in vivo;yeast 2-hybrid	8858162
COPA	ARFGAP1	No	in vitro;in vivo	12379802

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways

Gene mapped Reactome pathways