Gene Report

Basic Information

Approved Symbol	SYNJ2
Approved Name	synaptojanin 2
Symbol Alias	INPP5H
Location	6q25.3
Position	chr6:158517397-158520208 (+)
External Links	Entrez Gene: 8871 Ensembl: ENSG00000078269 UCSC: uc003qqx.2 HGNC ID: 11504
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SYNJ2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SYNJ2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SYNJ2 and other components at different levels (count: 0)

Positive relationship network of SYNJ2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SYNJ2 and MDD (count: 0)

Negative relationships between SYNJ2 and other components at different levels (count: 0)

SYNJ2 related SNPs in MK4MDD (count: 0)

SYNJ2 related proteins in MK4MDD (count: 0)

SYNJ2 related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	IEA
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045121	membrane raft	cellular component	IEA
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular function	IEA
GO:0046856	phosphatidylinositol dephosphorylation	biological process	IEA
GO:0030424	axon	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0003723	RNA binding	molecular function	IEA
GO:0006644	phospholipid metabolic process	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[15090612\|17474147\|20936779]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0005886	plasma membrane	cellular component	IEA
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS

SYNJ2 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04070	phosphatidylinositol signaling_system	Phosphatidylinositol signaling system

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00562	inositol phosphate_metabolism	Inositol phosphate metabolism

SYNJ2 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
NDKDYNAMIN_PATHWAY	ndkdynamin pathway	Endocytotic role of NDK, Phosphins and Dynamin	Reliable neurotransmitter release requires the presence of s...... Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve treminal proteins with little or no structural hoimology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coordinately dephosphorlyated in response to a calcium influx through voltage-dependent calicium channels. The calicium signal is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagination, fission and uncoating. In this diagram the internalization of the vesicle is the uncoating step. In order to illustrate the complexity of this process the initial display of the protein is labelled with a name and a number. This number is then used at the decloaking or uncoating step to show the release and seperation of the various factors. Each step in the process has a different set of complex components. The components are shown in highlighted boxes above. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2 (comma shaped molecule in the diagram). Nucleation is completed by the addition of epsin and eps15. Invagination proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The final components, dynamin and synaptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dynamin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After internalization the vesicle is quickly uncoated, in a process believed to be mediated by synaptojanin, and is accompnied by the disassembly of clathrin. More...

SYNJ2 related Reactome pathways (count: 0)

SYNJ2 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SYNJ2	NCK1	No	in vitro	10805734
SYNJ2	GRB2	No	in vitro;in vivo	9388224
SYNJ2	RAC1	No	in vitro;in vivo;yeast 2-hybrid	11084340
SYNJ2	SYNJ2BP	No	in vitro;in vivo	10357812
SYNJ2	SYNJ2	Yes	in vitro;in vivo;yeast 2-hybrid	10357812
SYNJ2	ITSN2	No	yeast 2-hybrid	12421765

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped BioCarta pathways