Gene Report

Basic Information

Approved Symbol	RAB2A
Approved Name	RAB2A, member RAS oncogene family
Previous Symbol	RAB2
Previous Name	"RAB2, member RAS oncogene family"
Location	8q12.1
Position	chr8:61533348-61535655 (+)
External Links	Entrez Gene: 5862 Ensembl: ENSG00000104388 UCSC: uc003xud.2 HGNC ID: 9763
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAB2A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAB2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between RAB2A and other components at different levels (count: 0)

Positive relationship network of RAB2A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAB2A and MDD (count: 0)

Negative relationships between RAB2A and other components at different levels (count: 0)

RAB2A related SNPs in MK4MDD (count: 0)

RAB2A related proteins in MK4MDD (count: 0)

RAB2A related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0042470	melanosome	cellular component	IEA
GO:0007030	Golgi organization	biological process	IMP[17684057]
GO:0032553	ribonucleotide binding	molecular function	IDA[16034420]
GO:0005525	GTP binding	molecular function	IDA[16034420]
GO:0032553	ribonucleotide binding	molecular function	IDA[16034420]
GO:0005515	protein binding	molecular function	IPI[16189514\|17684057\|21516116\|25416956]
GO:0005765	lysosomal membrane	cellular component	IDA[17897319]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|20458337\|23376485\|23533145]
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	IMP[17684057]
GO:0005634	nucleus	cellular component	IDA[21630459]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0007264	small GTPase mediated signal transduction	biological process	IEA
GO:0000139	Golgi membrane	cellular component	TAS
GO:0015031	protein transport	biological process	IEA
GO:0003924	GTPase activity	molecular function	IDA[16034420\|17562788\|17684057]
GO:0019003	GDP binding	molecular function	IDA[16034420]
GO:0000278	mitotic cell cycle	biological process	TAS
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	cellular component	IEA

RAB2A related KEGG pathways (count: 0)

RAB2A related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
RAB_PATHWAY	rab pathway	Rab GTPases Mark Targets In The Endocytotic Machinery	The eukaryotic cell contains compartments with distinct func...... The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes. The movement of membrane vesicles between these compartments allows proteins in the secretory pathway to move outward from the endoplasmic reticulum (ER) to the Golgi, trans Golgi network (TGN), secretory vesicles, and the plasma membrane and to be secreted into the extracellular environment. The trafficking of membrane vesicles is also essential for endocytosis and the movement of material from the extracellular environment into the early endosome (EE), late endosome (LE) and lysosome. The movement of vesicles and their contents between these compartments and their secretion are essential for a host of cellular functions, including the release of neurotransmitters and hormones. The movement of membrane vesicles between all of these compartments is regulated by members of the Rab family of GTPases, part of the ras superfamily of genes, regulated through binding of GTP and hydrolysis of bound GTP to GDP. At least eleven yeast genes in this family have been identified as Ypts, yeast transport proteins, and over sixty mammalian Rab genes have been identified in this highly conserved gene family. The products of the Rab genes regulate specific steps in vesicle transport. Rab1 is involved in the movement of membranes from the ER through the Golgi. Rab3 regulates secretory vesicle release and Rab27 is also involved in regulated release of secreted proteins. Rab5, 7 and 9 contribute to endocytosis while Rab4 and Rab11 mediate recycling from the endosome back to the plasma membrane. Rab11 is involved in both endocytosis and exocytosis. As with other Ras family GTPases, the activity of Rabs is regulated by guanine-nucleotide exchange factors (GEFs) and GAPs (GTPase activating proteins). Downstream effectors must also interact with Rabs to transmit their signals regulating each step of the membrane trafficking pathways including vesicle formation, movement of vesicles between compartments, vesicle docking, fusion and membrane remodeling. Downstream effectors of the Rabs include Rabphilin-3 (vesicle movement effector for Rab3), Rabphilin-11 (vesicle formation effector for Rab11), and EEA1 (vesicle fusion and membrane remodeling). If Rabs are involved in more than one role and other components of Rab signaling also interact with more than one Rab this will further increase the complexity of the system. Elucidating the interaction of Rabs and regulation of vesicle trafficking by other signaling pathways will be a key area of research in the future. More...

RAB2A related Reactome pathways (count: 0)

RAB2A related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAB2A	FAM71C	No	yeast 2-hybrid	16189514
RAB2A	BLZF1	No	in vitro;yeast 2-hybrid	11739401
RAB2A	PRKCI	Yes	in vitro;in vivo;yeast 2-hybrid	14570876
RAB2A	GOLGA2	Yes	in vitro;yeast 2-hybrid	11739401
RAB2A	GDI2	No	in vitro	10512627
RAB2A	GORASP2	No	in vitro	11739401
RAB2A	GAPDH	No	in vitro;in vivo	15485821
RAB2A	ZFYVE20	No	in vitro	16034420

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways