Gene Report

Basic Information

Approved Symbol	LTBP1
Approved Name	latent transforming growth factor beta binding protein 1
Name Alias	TGF-beta1-BP-1
Location	2p22-p21
Position	chr2:33172369-33624576 (+)
External Links	Entrez Gene: 4052 Ensembl: ENSG00000049323 UCSC: uc021vft.1 HGNC ID: 6714
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between LTBP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
LTBP1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between LTBP1 and other components at different levels (count: 0)

Positive relationship network of LTBP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LTBP1 and MDD (count: 0)

Negative relationships between LTBP1 and other components at different levels (count: 0)

LTBP1 related SNPs in MK4MDD (count: 0)

LTBP1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Latent-transforming growth factor beta-binding protein 1	Q14766	0(0/0)	Gene mapped

LTBP1 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031012	extracellular matrix	cellular component	IDA
GO:0005024	transforming growth factor beta-activated receptor activity	molecular function	NAS[8537398]
GO:0005578	proteinaceous extracellular matrix	cellular component	NAS[8537398]
GO:0019838	growth factor binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[18677313]
GO:0005509	calcium ion binding	molecular function	IEA
GO:0035583	sequestering of TGFbeta in extracellular matrix	biological process	TAS[18677313]

LTBP1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04350	tgf beta_signaling_pathway	TGF-beta signaling pathway	The transforming growth factor-beta (TGF-beta) family member...... The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. More...

LTBP1 related BioCarta pathways (count: 0)

LTBP1 related Reactome pathways (count: 0)

LTBP1 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LTBP1	ITGB5	Yes	in vitro;in vivo	12358597
LTBP1	FN1	No	in vitro	8756760
LTBP1	TGM2	No	in vitro	9060478
LTBP1	ATN1	No	yeast 2-hybrid	16713569
LTBP1	LTBP1	Yes	in vitro;in vivo	8617200 , 10930463
LTBP1	IGFBP3	No	yeast 2-hybrid	12962157
LTBP1	FBN1	No	in vitro;in vivo	12429738
LTBP1	FBN2	No	in vitro;in vivo	12429738

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways