Gene Report

Basic Information

Approved Symbol	NAPA
Approved Name	N-ethylmaleimide-sensitive factor attachment protein, alpha
Name Alias	alpha SNAP
Location	19q13.33
Position	chr19:47990891-48018515 (-)
External Links	Entrez Gene: 8775 Ensembl: ENSG00000105402 UCSC: uc002pha.2 HGNC ID: 7641
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between NAPA and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NAPA	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between NAPA and other components at different levels (count: 0)

Positive relationship network of NAPA in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NAPA and MDD (count: 0)

Negative relationships between NAPA and other components at different levels (count: 0)

NAPA related SNPs in MK4MDD (count: 0)

NAPA related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Alpha-soluble NSF attachment protein	P54920	0(0/0)	Gene mapped

NAPA related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030182	neuron differentiation	biological process	IEA
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045176	apical protein localization	biological process	IEA
GO:0007420	brain development	biological process	IEA
GO:0019905	syntaxin binding	molecular function	IEA
GO:0006886	intracellular protein transport	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16189514]
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	cellular component	IEA
GO:0010807	regulation of synaptic vesicle priming	biological process	IEA
GO:0006891	intra-Golgi vesicle-mediated transport	biological process	TAS[8455721]
GO:0006892	post-Golgi vesicle-mediated transport	biological process	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0035494	SNARE complex disassembly	biological process	IEA
GO:0016044	cellular membrane organization	biological process	TAS
GO:0006944	cellular membrane fusion	biological process	TAS[8455721]

NAPA related KEGG pathways (count: 0)

NAPA related BioCarta pathways (count: 0)

NAPA related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19400	golgi associated_vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. More...
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...

NAPA related interactors from protein-protein interaction data in HPRD (count: 15)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NAPA	STX12	No	in vitro	9507000 , 9817754
NAPA	NSF	No	in vivo	9362506
NAPA	STX1A	Yes	in vitro	7622514
NAPA	TRPC3	No	in vivo;yeast 2-hybrid	15327778
NAPA	STX5	No	yeast 2-hybrid	16189514
NAPA	STX8	No	in vivo	10683148
NAPA	VAMP8	No	in vitro	9614193
NAPA	RTN4	No	yeast 2-hybrid	16189514
NAPA	BNIP1	No	in vitro	15272311
NAPA	SNAP23	Yes	yeast 2-hybrid	16189514
NAPA	STX4	No	yeast 2-hybrid	16189514
NAPA	GNA12	No	in vitro;yeast 2-hybrid	15980433
NAPA	STX7	No	in vitro	9417091
NAPA	GOSR2	No	in vitro;in vivo	9349823
NAPA	GOSR1	No	in vitro;in vivo	8636227 , 9325254

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways