Gene Report

Basic Information

Approved Symbol	CAP2
Approved Name	CAP, adenylate cyclase-associated protein, 2 (yeast)
Location	6p22.3
Position	chr6:17393736-17558023 (+)
External Links	Entrez Gene: 10486 Ensembl: ENSG00000112186 UCSC: uc003ncb.3 HGNC ID: 20039
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CAP2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CAP2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between CAP2 and other components at different levels (count: 0)

Positive relationship network of CAP2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CAP2 and MDD (count: 0)

Negative relationships between CAP2 and other components at different levels (count: 0)

CAP2 related SNPs in MK4MDD (count: 0)

CAP2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Adenylyl cyclase-associated protein 2	P40123	0(0/0)	Gene mapped

CAP2 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007411	axon guidance	biological process	TAS
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[7962207]
GO:0007165	signal transduction	biological process	TAS[7962207]
GO:0005886	plasma membrane	cellular component	IEA
GO:0007163	establishment or maintenance of cell polarity	biological process	TAS[7962207]
GO:0007010	cytoskeleton organization	biological process	IEA
GO:0003779	actin binding	molecular function	IEA

CAP2 related KEGG pathways (count: 0)

CAP2 related BioCarta pathways (count: 0)

CAP2 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_18266	axon guidance	Axon guidance / axon pathfinding is the process by which neu...... Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the surrounding environment provide the necessary directional information for the trip. These extrinsic cues have been divided into attractive or repulsive signals that tell the growth cone where and where not to grow. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules and their receptors that guide axons. These include netrins, Slits, semaphorins, and ephrins, and their cognate receptors, DCC and or uncoordinated-5 (UNC5), roundabouts (Robo), neuropilin and Eph. In addition, many other classes of adhesion molecules are also used by growth cones to navigate properly which include NCAM and L1CAM. More...
REACT_19351	signaling by_robo_receptor	The Roundabout (Robo) family encodes transmembrane receptors...... The Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growth cones. There are four human Robo homologues, Robo1, Robo2, Robo3 and Robo4. Most of the Robos have the similar ectodomain architecture as the cell adhesion molecules, five Ig domains followed by three FN3 repeats except for Robo4, it has 2Ig and 2FN3 repeats. The cytoplasmic domains of Robo receptors are in general poorly conserved. However, there are four short conserved cytoplasmic sequence motifs, named CC0-3, that serve as binding sites for adaptor proteins. The ligands for the human Robo receptors are the three Slit proteins Slit1, Slit2, and Slit3; all of the Slit proteins contain a tandem of four LRR (leucine rich repeat) domains at N terminus, termed D1 D4 followed by six EGF (epidermal growth factor)-like domains, a laminin G like domain (ALPS), three EGF-like domains, and a C-terminal cysteine knot domain. Most Slit proteins are cleaved within the EGF-like region by unknown proteases. Slit protein binding modulates Robo interactions with the cytosolic adaptors. The cytoplasmic domain of Robo1 and Robo2 determines the repulsive responses of these receptors. Based on the studies from both invertebrate and vertebrate organisms its been inferred that Robo induces growth cone repulsion by controlling cytoskeletal dynamics via either Abelson kinase (Abl) and Enabled (Ena), or Rac activity. More...

CAP2 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CAP2	ACTG1	No	in vivo	8761950
CAP2	CAP1	No	in vivo;yeast 2-hybrid	8761950
CAP2	PRPF40A	No	yeast 2-hybrid	15231748

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways